Project acronym APOSITE
Project Apoptotic foci: composition, structure and dynamics
Researcher (PI) Ana GARCIA SAEZ
Host Institution (HI) UNIVERSITAET ZU KOELN
Country Germany
Call Details Consolidator Grant (CoG), LS3, ERC-2018-COG
Summary Apoptotic cell death is essential for development, immune function or tissue homeostasis, and it is often deregulated in disease. Mitochondrial outer membrane permeabilization (MOMP) is central for apoptosis execution and plays a key role in its inflammatory outcome. Knowing the architecture of the macromolecular machineries mediating MOMP is crucial for understanding their function and for the clinical use of apoptosis.
Our recent work reveals that Bax and Bak dimers form distinct line, arc and ring assemblies at specific apoptotic foci to mediate MOMP. However, the molecular structure and mechanisms controlling the spatiotemporal formation and range of action of the apoptotic foci are missing. To address this fundamental gap in our knowledge, we aim to unravel the composition, dynamics and structure of apoptotic foci and to understand how they are integrated to orchestrate function. We will reach this goal by building on our expertise in cell death and cutting-edge imaging and by developing a new analytical pipeline to:
1) Identify the composition of apoptotic foci using in situ proximity-dependent labeling and extraction of near-native Bax/Bak membrane complexes coupled to mass spectrometry.
2) Define their contribution to apoptosis and its immunogenicity and establish their assembly dynamics to correlate it with apoptosis progression by live cell imaging.
3) Determine the stoichiometry and structural organization of the apoptotic foci by combining single molecule fluorescence and advanced electron microscopies.
This multidisciplinary approach offers high chances to solve the long-standing question of how Bax and Bak mediate MOMP. APOSITE will provide textbook knowledge of the mitochondrial contribution to cell death and inflammation. The implementation of this new analytical framework will open novel research avenues in membrane and organelle biology. Ultimately, understanding of Bax and Bak structure/function will help develop apoptosis modulators for medicine.
Summary
Apoptotic cell death is essential for development, immune function or tissue homeostasis, and it is often deregulated in disease. Mitochondrial outer membrane permeabilization (MOMP) is central for apoptosis execution and plays a key role in its inflammatory outcome. Knowing the architecture of the macromolecular machineries mediating MOMP is crucial for understanding their function and for the clinical use of apoptosis.
Our recent work reveals that Bax and Bak dimers form distinct line, arc and ring assemblies at specific apoptotic foci to mediate MOMP. However, the molecular structure and mechanisms controlling the spatiotemporal formation and range of action of the apoptotic foci are missing. To address this fundamental gap in our knowledge, we aim to unravel the composition, dynamics and structure of apoptotic foci and to understand how they are integrated to orchestrate function. We will reach this goal by building on our expertise in cell death and cutting-edge imaging and by developing a new analytical pipeline to:
1) Identify the composition of apoptotic foci using in situ proximity-dependent labeling and extraction of near-native Bax/Bak membrane complexes coupled to mass spectrometry.
2) Define their contribution to apoptosis and its immunogenicity and establish their assembly dynamics to correlate it with apoptosis progression by live cell imaging.
3) Determine the stoichiometry and structural organization of the apoptotic foci by combining single molecule fluorescence and advanced electron microscopies.
This multidisciplinary approach offers high chances to solve the long-standing question of how Bax and Bak mediate MOMP. APOSITE will provide textbook knowledge of the mitochondrial contribution to cell death and inflammation. The implementation of this new analytical framework will open novel research avenues in membrane and organelle biology. Ultimately, understanding of Bax and Bak structure/function will help develop apoptosis modulators for medicine.
Max ERC Funding
2 000 000 €
Duration
Start date: 2019-04-01, End date: 2024-03-31
Project acronym ASTROFLOW
Project The influence of stellar outflows on exoplanetary mass loss
Researcher (PI) Aline VIDOTTO
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), PE9, ERC-2018-COG
Summary ASTROFLOW aims to make ground-breaking progress in our physical understanding of exoplanetary mass loss, by quantifying the influence of stellar outflows on atmospheric escape of close-in exoplanets. Escape plays a key role in planetary evolution, population, and potential to develop life. Stellar irradiation and outflows affect planetary mass loss: irradiation heats planetary atmospheres, which inflate and more likely escape; outflows cause pressure confinement around otherwise freely escaping atmospheres. This external pressure can increase, reduce or even suppress escape rates; its effects on exoplanetary mass loss remain largely unexplored due to the complexity of such interactions. I will fill this knowledge gap by developing a novel modelling framework of atmospheric escape that will, for the first time, consider the effects of realistic stellar outflows on exoplanetary mass loss. My expertise in stellar wind theory and 3D magnetohydrodynamic simulations is crucial for producing the next-generation models of planetary escape. My framework will consist of state-of-the-art, time-dependent, 3D simulations of stellar outflows (Method 1), which will be coupled to novel 3D simulations of atmospheric escape (Method 2). My models will account for the major underlying physical processes of mass loss. With this, I will determine the response of planetary mass loss to realistic stellar particle, magnetic and radiation environments and will characterise the physical conditions of the escaping material. I will compute how its extinction varies during transit and compare synthetic line profiles to atmospheric escape observations from, eg, Hubble and our NASA cubesat CUTE. Strong synergy with upcoming observations (JWST, TESS, SPIRou, CARMENES) also exists. Determining the lifetime of planetary atmospheres is essential to understanding populations of exoplanets. ASTROFLOW’s work will be the foundation for future research of how exoplanets evolve under mass-loss processes.
Summary
ASTROFLOW aims to make ground-breaking progress in our physical understanding of exoplanetary mass loss, by quantifying the influence of stellar outflows on atmospheric escape of close-in exoplanets. Escape plays a key role in planetary evolution, population, and potential to develop life. Stellar irradiation and outflows affect planetary mass loss: irradiation heats planetary atmospheres, which inflate and more likely escape; outflows cause pressure confinement around otherwise freely escaping atmospheres. This external pressure can increase, reduce or even suppress escape rates; its effects on exoplanetary mass loss remain largely unexplored due to the complexity of such interactions. I will fill this knowledge gap by developing a novel modelling framework of atmospheric escape that will, for the first time, consider the effects of realistic stellar outflows on exoplanetary mass loss. My expertise in stellar wind theory and 3D magnetohydrodynamic simulations is crucial for producing the next-generation models of planetary escape. My framework will consist of state-of-the-art, time-dependent, 3D simulations of stellar outflows (Method 1), which will be coupled to novel 3D simulations of atmospheric escape (Method 2). My models will account for the major underlying physical processes of mass loss. With this, I will determine the response of planetary mass loss to realistic stellar particle, magnetic and radiation environments and will characterise the physical conditions of the escaping material. I will compute how its extinction varies during transit and compare synthetic line profiles to atmospheric escape observations from, eg, Hubble and our NASA cubesat CUTE. Strong synergy with upcoming observations (JWST, TESS, SPIRou, CARMENES) also exists. Determining the lifetime of planetary atmospheres is essential to understanding populations of exoplanets. ASTROFLOW’s work will be the foundation for future research of how exoplanets evolve under mass-loss processes.
Max ERC Funding
1 999 956 €
Duration
Start date: 2019-09-01, End date: 2024-08-31
Project acronym ChromoSOMe
Project Canonical and Non-canonical modes of Chromosome Segregation in Oocyte Meiosis
Researcher (PI) Julien Dumont
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Country France
Call Details Consolidator Grant (CoG), LS3, ERC-2018-COG
Summary Cell division is crucial for the development of complex organisms, for the homeostasis of tissues, and for the reproductive capacity of individuals. While most somatic cells are diploid and proliferate through mitosis, multiplication of sexually reproducing species relies on haploid gametes that are generated through a specialized cell division process called meiosis. To achieve this reduction in ploidy, two rounds of chromosome segregation follow a single phase of genome replication. Inaccuracy in this process leads to gametes that carry an incorrect number of chromosomes and to aneuploid embryos after fertilization. In their vast majority, these are non-viable and lead to spontaneous abortion: defective meiotic division is therefore a major obstacle in achieving reproduction. However, the key principles that drive this process are still poorly understood, one main reason being the diversity of the molecular scenarios that have been adopted across evolution to regulate oocyte chromosome segregation.
To dissect the key components of oocyte meiotic chromosome segregation, we propose to carry out a multi-disciplinary approach, combining several nematode species with the use of high-resolution live and electron microscopy, cutting edge genomic and proteomic technologies, and biochemistry coupled to in silico modeling. In Work Package 1 (WP1), we will analyze the molecular mechanisms controlling the self-assembly of the chromosome segregation machinery -the meiotic spindle- in the oocyte. WP2 will focus on defining how chromosome segregation is achieved in oocytes with non-canonical kinetochore geometry. WP3 aims at analyzing meiotic divisions in parthenogenetic nematodes with specific meiotic constraints, such as centrosomal oogenesis and unichromosomal genomes. By considering the wealth of mechanisms that can drive chromosome segregation in oocytes, this project will provide decisive steps towards understanding the essential and universal features of female meiosis.
Summary
Cell division is crucial for the development of complex organisms, for the homeostasis of tissues, and for the reproductive capacity of individuals. While most somatic cells are diploid and proliferate through mitosis, multiplication of sexually reproducing species relies on haploid gametes that are generated through a specialized cell division process called meiosis. To achieve this reduction in ploidy, two rounds of chromosome segregation follow a single phase of genome replication. Inaccuracy in this process leads to gametes that carry an incorrect number of chromosomes and to aneuploid embryos after fertilization. In their vast majority, these are non-viable and lead to spontaneous abortion: defective meiotic division is therefore a major obstacle in achieving reproduction. However, the key principles that drive this process are still poorly understood, one main reason being the diversity of the molecular scenarios that have been adopted across evolution to regulate oocyte chromosome segregation.
To dissect the key components of oocyte meiotic chromosome segregation, we propose to carry out a multi-disciplinary approach, combining several nematode species with the use of high-resolution live and electron microscopy, cutting edge genomic and proteomic technologies, and biochemistry coupled to in silico modeling. In Work Package 1 (WP1), we will analyze the molecular mechanisms controlling the self-assembly of the chromosome segregation machinery -the meiotic spindle- in the oocyte. WP2 will focus on defining how chromosome segregation is achieved in oocytes with non-canonical kinetochore geometry. WP3 aims at analyzing meiotic divisions in parthenogenetic nematodes with specific meiotic constraints, such as centrosomal oogenesis and unichromosomal genomes. By considering the wealth of mechanisms that can drive chromosome segregation in oocytes, this project will provide decisive steps towards understanding the essential and universal features of female meiosis.
Max ERC Funding
1 561 563 €
Duration
Start date: 2020-01-01, End date: 2024-12-31
Project acronym COLLEXISM
Project Collisional excitation of interstellar molecules: towards reactive systems
Researcher (PI) Francois LIQUE
Host Institution (HI) UNIVERSITE LE HAVRE NORMANDIE
Country France
Call Details Consolidator Grant (CoG), PE9, ERC-2018-COG
Summary Accurate determination of physical conditions of interstellar molecular clouds is a crucial step to better understand the life cycle of the interstellar matter and particularly the formation of stars and planets as well as the synthesis of organic molecules that may lead to emergence of life in the universe. A key parameter for the determination of these conditions from interstellar spectra is the calculation of accurate collisional rate coefficients of interstellar molecules with the most abundant species (H, He, H2 and e-). Whereas the knowledge of collisional processes has reached a certain level of maturity for collisions involving non-reactive molecules, very few reliable data exist for collisions involving reactive radicals and ions. The computation of such data is a real challenge since inelastic and reactive processes compete during collisions. In this project, we plan to overcome this complex problem and to provide collisional data for these radicals and ions in order to derive as much information as possible from the molecular spectra collected by current telescopes. As it is hardly possible to consider both collisional and reactive processes simultaneously, we will set up a new methodology based on quantum approach that allows obtaining accurate data. We will focus on molecular hydrides that are good candidates because of both their astrophysical importance and their quantum accessibility. We will carry out the determination of interaction potentials using quantum chemistry ab initio methods while the treatment of the dynamics of the nuclei will primarily be done using quantum time-independent reactive and non-reactive approaches. When exact quantum calculations will not be usable, innovative statistical quantum mechanical methods will also be explored. The new data will then be used in radiative transfer models and the predictions will be finally compared to observations in order to derive the abundances of reactive radicals with unprecedented accuracy.
Summary
Accurate determination of physical conditions of interstellar molecular clouds is a crucial step to better understand the life cycle of the interstellar matter and particularly the formation of stars and planets as well as the synthesis of organic molecules that may lead to emergence of life in the universe. A key parameter for the determination of these conditions from interstellar spectra is the calculation of accurate collisional rate coefficients of interstellar molecules with the most abundant species (H, He, H2 and e-). Whereas the knowledge of collisional processes has reached a certain level of maturity for collisions involving non-reactive molecules, very few reliable data exist for collisions involving reactive radicals and ions. The computation of such data is a real challenge since inelastic and reactive processes compete during collisions. In this project, we plan to overcome this complex problem and to provide collisional data for these radicals and ions in order to derive as much information as possible from the molecular spectra collected by current telescopes. As it is hardly possible to consider both collisional and reactive processes simultaneously, we will set up a new methodology based on quantum approach that allows obtaining accurate data. We will focus on molecular hydrides that are good candidates because of both their astrophysical importance and their quantum accessibility. We will carry out the determination of interaction potentials using quantum chemistry ab initio methods while the treatment of the dynamics of the nuclei will primarily be done using quantum time-independent reactive and non-reactive approaches. When exact quantum calculations will not be usable, innovative statistical quantum mechanical methods will also be explored. The new data will then be used in radiative transfer models and the predictions will be finally compared to observations in order to derive the abundances of reactive radicals with unprecedented accuracy.
Max ERC Funding
1 802 625 €
Duration
Start date: 2019-07-01, End date: 2024-06-30
Project acronym COQCOoN
Project COntinuous variables Quantum COmplex Networks
Researcher (PI) Valentina PARIGI
Host Institution (HI) SORBONNE UNIVERSITE
Country France
Call Details Consolidator Grant (CoG), PE2, ERC-2018-COG
Summary At different scales, from molecular systems to technological infrastructures, physical systems group in structures which are neither simply regular or random, but can be represented by networks with complex shape. Proteins in metabolic structures and the World Wide Web, for example, share the same kind of statistical distribution of connections of their constituents. In addition, the individual elements of natural samples, like atoms or electrons, are quantum objects. Hence replicating complex networks in a scalable quantum platform is a formidable opportunity to learn more about the intrinsic quantumness of real world and for the efficient exploitation of quantum-complex structures in future technologies. Future trusted large-scale communications and efficient big data handling, in fact, will depend on at least one of the two aspects -quantum or complex- of scalable systems, or on an appropriate combination of the two.
In COQCOoN I will tackle both the quantum and the complex structure of physical systems. I will implement large quantum complex networks via multimode quantum systems based on both temporal and frequency modes of parametric processes pumped by pulsed lasers. Quantum correlations between amplitude and phase continuous variables will be arranged in complex topologies and delocalized single and multiple photon excitations will be distributed in the network. I aim at:
-Learn from nature: I will reproduce complex topologies in the quantum network to query the quantum properties of natural processes, like energy transport and synchronization, and investigate how nature-inspired efficient strategies can be transferred in quantum technologies.
-Control large quantum architectures: I will experiment network topologies that make quantum communication and information protocols resilient against internal failures and environmental changes. I will setup distant multi-party quantum communications and quantum simulation in complex networks.
Summary
At different scales, from molecular systems to technological infrastructures, physical systems group in structures which are neither simply regular or random, but can be represented by networks with complex shape. Proteins in metabolic structures and the World Wide Web, for example, share the same kind of statistical distribution of connections of their constituents. In addition, the individual elements of natural samples, like atoms or electrons, are quantum objects. Hence replicating complex networks in a scalable quantum platform is a formidable opportunity to learn more about the intrinsic quantumness of real world and for the efficient exploitation of quantum-complex structures in future technologies. Future trusted large-scale communications and efficient big data handling, in fact, will depend on at least one of the two aspects -quantum or complex- of scalable systems, or on an appropriate combination of the two.
In COQCOoN I will tackle both the quantum and the complex structure of physical systems. I will implement large quantum complex networks via multimode quantum systems based on both temporal and frequency modes of parametric processes pumped by pulsed lasers. Quantum correlations between amplitude and phase continuous variables will be arranged in complex topologies and delocalized single and multiple photon excitations will be distributed in the network. I aim at:
-Learn from nature: I will reproduce complex topologies in the quantum network to query the quantum properties of natural processes, like energy transport and synchronization, and investigate how nature-inspired efficient strategies can be transferred in quantum technologies.
-Control large quantum architectures: I will experiment network topologies that make quantum communication and information protocols resilient against internal failures and environmental changes. I will setup distant multi-party quantum communications and quantum simulation in complex networks.
Max ERC Funding
1 990 000 €
Duration
Start date: 2019-06-01, End date: 2024-11-30
Project acronym DeCoCt
Project Knowledge based design of complex synthetic microbial communities for plant protection
Researcher (PI) Eric Kemen
Host Institution (HI) EBERHARD KARLS UNIVERSITAET TUEBINGEN
Country Germany
Call Details Consolidator Grant (CoG), LS9, ERC-2018-COG
Summary "Complex microbial communities (""microbiota"") that populate surfaces of higher organisms critically impact health of their hosts: They contribute to vital functions such as host fitness, nutrient acquisition, stress tolerance and pathogen resistance but are, at the same time, reservoirs for facultative pathogens or can promote pathogenesis. How and why communities shift from a beneficial to a detrimental state is largely unknown and we are far from utilizing identified mechanisms.
In order to cure detrimental microbiota, that were damaged or reverted through stress factors including previous diseases, decoding the complex processes governing microbiota dynamics is a key challenge. To develop durable probiotics, communal stability or the ability of a community to return to a steady state following perturbation is a key factor.
Our lab has broad expertise in studying microbial communities through lab experiments and analyzing factors that shape the microbiota of Arabidopsis thaliana plants under natural conditions and common garden experiments. We have discovered a hierarchical order in microbial community networks with hub microbes as key elements. A recent breakthrough was the discovery of microbial taxa that persist throughout the life of A. thaliana plants and their importance in network stability.
In this project we will use our expertise to identify key stability factors and drivers of communal dynamics to reconstitute synthetic communities. How to seed microbial communities that develop into functional probiotics is a key challenge. We will use knowledge based assembly of complex communities to seeds protective microbiota. We will challenge those through pathogens and abiotic factors to refine and test the predictive power of our analyses. Therefore, DeCoCt represents a highly innovative approach that holds the potential to gain novel insights beyond the current scope of microbiota and probiotics research."
Summary
"Complex microbial communities (""microbiota"") that populate surfaces of higher organisms critically impact health of their hosts: They contribute to vital functions such as host fitness, nutrient acquisition, stress tolerance and pathogen resistance but are, at the same time, reservoirs for facultative pathogens or can promote pathogenesis. How and why communities shift from a beneficial to a detrimental state is largely unknown and we are far from utilizing identified mechanisms.
In order to cure detrimental microbiota, that were damaged or reverted through stress factors including previous diseases, decoding the complex processes governing microbiota dynamics is a key challenge. To develop durable probiotics, communal stability or the ability of a community to return to a steady state following perturbation is a key factor.
Our lab has broad expertise in studying microbial communities through lab experiments and analyzing factors that shape the microbiota of Arabidopsis thaliana plants under natural conditions and common garden experiments. We have discovered a hierarchical order in microbial community networks with hub microbes as key elements. A recent breakthrough was the discovery of microbial taxa that persist throughout the life of A. thaliana plants and their importance in network stability.
In this project we will use our expertise to identify key stability factors and drivers of communal dynamics to reconstitute synthetic communities. How to seed microbial communities that develop into functional probiotics is a key challenge. We will use knowledge based assembly of complex communities to seeds protective microbiota. We will challenge those through pathogens and abiotic factors to refine and test the predictive power of our analyses. Therefore, DeCoCt represents a highly innovative approach that holds the potential to gain novel insights beyond the current scope of microbiota and probiotics research."
Max ERC Funding
1 925 500 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym ECOFEED
Project Altered eco-evolutionary feedbacks in a future climate
Researcher (PI) Julien COTE
Host Institution (HI) CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Country France
Call Details Consolidator Grant (CoG), LS8, ERC-2018-COG
Summary Current scenarios predict an accelerated biodiversity erosion with climate change. However, uncertainties in predictions remain large because the multitude of climate change effects from genes to ecosystems and their interdependencies are still overlooked. This incomplete vision hampers the development of effective mitigation strategies to sustain biodiversity.
Climate change can directly modify the phenotype and performance of individuals through phenotypic plasticity and evolution on contemporary time scales. The microevolution of keystone species can spread throughout the whole ecological network due to changes in species interactions and further translate into an altered ecosystem functioning. Conversely, direct impacts on communities and ecosystems can have ripple effects on the phenotypic distribution and evolution of all species of ecological networks.
Climate-driven changes at individual and population levels can shape community composition and ecosystem functioning, and vice versa, altering eco-evolutionary feedbacks, namely the reciprocal interactions between ecological and evolutionary processes. Climate-driven ecological and evolutionary dynamics are yet often investigated separately. The role of eco-evolutionary feedbacks in climate change impacts on biological systems therefore hinges on little concrete empirical evidence contrasting with a profuse theoretical development.
ECOFEED will investigate climate-dependent eco-evolutionary feedbacks using a 6 year-long realistic warming experiment reproducing natural conditions and thus allowing for both evolutionary and ecological dynamics to occur under a predicted climate change scenario. Complementary laboratory experiments will quantify reciprocal impacts of climate-dependent evolutionary and ecological changes on each other. ECOFEED will provide unprecedented insights on the eco-evolutionary feedbacks in a future climate and will ultimately help refine predictions on the future of biodiversity.
Summary
Current scenarios predict an accelerated biodiversity erosion with climate change. However, uncertainties in predictions remain large because the multitude of climate change effects from genes to ecosystems and their interdependencies are still overlooked. This incomplete vision hampers the development of effective mitigation strategies to sustain biodiversity.
Climate change can directly modify the phenotype and performance of individuals through phenotypic plasticity and evolution on contemporary time scales. The microevolution of keystone species can spread throughout the whole ecological network due to changes in species interactions and further translate into an altered ecosystem functioning. Conversely, direct impacts on communities and ecosystems can have ripple effects on the phenotypic distribution and evolution of all species of ecological networks.
Climate-driven changes at individual and population levels can shape community composition and ecosystem functioning, and vice versa, altering eco-evolutionary feedbacks, namely the reciprocal interactions between ecological and evolutionary processes. Climate-driven ecological and evolutionary dynamics are yet often investigated separately. The role of eco-evolutionary feedbacks in climate change impacts on biological systems therefore hinges on little concrete empirical evidence contrasting with a profuse theoretical development.
ECOFEED will investigate climate-dependent eco-evolutionary feedbacks using a 6 year-long realistic warming experiment reproducing natural conditions and thus allowing for both evolutionary and ecological dynamics to occur under a predicted climate change scenario. Complementary laboratory experiments will quantify reciprocal impacts of climate-dependent evolutionary and ecological changes on each other. ECOFEED will provide unprecedented insights on the eco-evolutionary feedbacks in a future climate and will ultimately help refine predictions on the future of biodiversity.
Max ERC Funding
1 983 565 €
Duration
Start date: 2019-04-01, End date: 2024-03-31
Project acronym EQUALITY
Project CORRECTING INEQUALITY THROUGH LAW: HOW COURTS CONCEPTUALIZE EQUALITY IN THEIR CONSTITUTIONAL JURISPRUDENCE
Researcher (PI) Niels Petersen
Host Institution (HI) WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Country Germany
Call Details Consolidator Grant (CoG), SH2, ERC-2018-COG
Summary Equality is one of the main political concerns of our time. Rising economic inequality is often cited as a major reason for the recent rise of political populism. But economic inequality is not the only problem. Inequalities based on gender, race or nationality are also major issues in the contemporary discussion. While most commentators discuss political solutions, the proposed research project analyzes the contributions that courts can make to correct inequalities. Norms protecting equality form part of all major national and international human rights instruments. However, the meaning of equality is fundamentally contested. There is no agreement on what equality exactly means or entails. The question, therefore, is not whether legal equality guarantees can tolerate inequality, but to what extent they can do. Because of these conceptual difficulties, the application of equality and non-discrimination clauses is not a straightforward exercise, in which courts simply apply legal norms to a given set of facts. Instead, courts need to develop doctrinal instruments to give meaning to the concept of equality. The proposed research project analyses how apex courts conceptualize equality in constitutional and international human rights law. It will be based on a comparative study of the equality jurisprudence of 16 jurisdictions and has three aims. Firstly, it intends to create a comparative map of equality jurisprudence, i.e. to describe and categorize the constitutional jurisprudence on equality: Which doctrinal choices do courts make and how do these choices inform the conception of equality? Secondly, it seeks to explain the doctrinal choices of the analyzed courts: Which factors influence courts to arrive at particular conceptions of equality? Thirdly, it has a normative goal and examines whether courts are better suited to correct certain kinds of inequalities than other kinds of inequalities.
Summary
Equality is one of the main political concerns of our time. Rising economic inequality is often cited as a major reason for the recent rise of political populism. But economic inequality is not the only problem. Inequalities based on gender, race or nationality are also major issues in the contemporary discussion. While most commentators discuss political solutions, the proposed research project analyzes the contributions that courts can make to correct inequalities. Norms protecting equality form part of all major national and international human rights instruments. However, the meaning of equality is fundamentally contested. There is no agreement on what equality exactly means or entails. The question, therefore, is not whether legal equality guarantees can tolerate inequality, but to what extent they can do. Because of these conceptual difficulties, the application of equality and non-discrimination clauses is not a straightforward exercise, in which courts simply apply legal norms to a given set of facts. Instead, courts need to develop doctrinal instruments to give meaning to the concept of equality. The proposed research project analyses how apex courts conceptualize equality in constitutional and international human rights law. It will be based on a comparative study of the equality jurisprudence of 16 jurisdictions and has three aims. Firstly, it intends to create a comparative map of equality jurisprudence, i.e. to describe and categorize the constitutional jurisprudence on equality: Which doctrinal choices do courts make and how do these choices inform the conception of equality? Secondly, it seeks to explain the doctrinal choices of the analyzed courts: Which factors influence courts to arrive at particular conceptions of equality? Thirdly, it has a normative goal and examines whether courts are better suited to correct certain kinds of inequalities than other kinds of inequalities.
Max ERC Funding
1 606 597 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
Project acronym FIAT
Project The Foundations of Institutional AuThority: a multi-dimensional model of the separation of powers
Researcher (PI) Eoin CAROLAN
Host Institution (HI) UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Country Ireland
Call Details Consolidator Grant (CoG), SH2, ERC-2018-COG
Summary ‘Almost three centuries later, it is past time to rethink Montesquieu’s holy trinity’ (Ackerman, 2010).
As Ackerman (and many others) have observed, political reality has long left the traditional model of the separation of powers behind. The problems posed by this gap between constitutional theory and political practice have recently acquired fresh urgency as developments in Hungary, Poland, Turkey, Russia, the UK, US, Bolivia and elsewhere place the separation of powers under strain. These include the emergence of authoritarian leaders; personalisation of political authority; recourse to non-legal plebiscites; and the capture or de-legitimisation of other constitutional bodies.
This project argues that these difficulties are rooted in a deeper problem with constitutional thinking about institutional power: a constitution-as-law approach that equates the conferral of legal power with the authority to exercise it. This makes it possible for a gap to emerge between legal accounts of authority and its diverse –and potentially conflicting (Cotterrell)– sociological foundations. Where that gap exists, the practical authority of an institution (or constitution) may be vulnerable to challenge from rival and more socially-resonant claims (Scheppele (2017)).
It is this gap between legal norms and social facts that the project aims to investigate – and ultimately bridge.
How is authority established? How is it maintained? How might it fail? And how does the constitution (as rule? representation (Saward)? mission statement (King)?) shape, re-shape and come to be shaped by those processes? By investigating these questions across six case studies, the project will produce a multi-dimensional account of institutional authority that takes seriously the sociological influence of both law and culture.
The results from these cases provide the evidential foundation for the project’s final outputs: a new model and new evaluative measures of the separation of powers.
Summary
‘Almost three centuries later, it is past time to rethink Montesquieu’s holy trinity’ (Ackerman, 2010).
As Ackerman (and many others) have observed, political reality has long left the traditional model of the separation of powers behind. The problems posed by this gap between constitutional theory and political practice have recently acquired fresh urgency as developments in Hungary, Poland, Turkey, Russia, the UK, US, Bolivia and elsewhere place the separation of powers under strain. These include the emergence of authoritarian leaders; personalisation of political authority; recourse to non-legal plebiscites; and the capture or de-legitimisation of other constitutional bodies.
This project argues that these difficulties are rooted in a deeper problem with constitutional thinking about institutional power: a constitution-as-law approach that equates the conferral of legal power with the authority to exercise it. This makes it possible for a gap to emerge between legal accounts of authority and its diverse –and potentially conflicting (Cotterrell)– sociological foundations. Where that gap exists, the practical authority of an institution (or constitution) may be vulnerable to challenge from rival and more socially-resonant claims (Scheppele (2017)).
It is this gap between legal norms and social facts that the project aims to investigate – and ultimately bridge.
How is authority established? How is it maintained? How might it fail? And how does the constitution (as rule? representation (Saward)? mission statement (King)?) shape, re-shape and come to be shaped by those processes? By investigating these questions across six case studies, the project will produce a multi-dimensional account of institutional authority that takes seriously the sociological influence of both law and culture.
The results from these cases provide the evidential foundation for the project’s final outputs: a new model and new evaluative measures of the separation of powers.
Max ERC Funding
1 997 628 €
Duration
Start date: 2020-01-01, End date: 2024-12-31
Project acronym LHCtoLISA
Project Precision Gravity: From the LHC to LISA
Researcher (PI) Rafael Alejandro PORTO PEREIRA
Host Institution (HI) STIFTUNG DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY
Country Germany
Call Details Consolidator Grant (CoG), PE2, ERC-2018-COG
Summary The nascent field of gravitational wave (GW) science will be an interdisciplinary subject, enriching different branches of physics, yet the associated computational challenges are enormous. Faithful theoretical templates are a compulsory ingredient for successful data analysis and reliable physical interpretation of the signals. This is critical, for instance, to study the equation of state of neutron stars, the nature of black holes, and binary formation channels. However, while current templates for compact binary sources may be sufficient for detection and crude parameter estimation, they are too coarse for precision physics with GW data. We then find ourselves in a situation in which, for key processes within empirical reach, theoretical uncertainties may dominate. To move forward, profiting the most from GW observations, more accurate waveforms will be needed.
I have played a pioneering role in the development and implementation of a new formalism, known as the ‘effective field theory approach’, which has been instrumental for the construction of the state-of-the-art GW template bank. The goal of my proposal is thus to redefine the frontiers of analytic understanding in gravity through the effective field theory framework. Even more ambitiously, to go beyond the current computational paradigm with powerful tools which have been crucial for `new-physics' searches at the Large Hadron Collider.
The impact of the high-accuracy calculations I propose to undertake will be immense: from probes of dynamical spacetime and strongly interacting matter, to the potential to discover exotic compact objects and ultra-light particles in nature. Furthermore, GW observations scan gravity in a regime which is otherwise unexplored. Consequently, the coming decade will tell whether Einstein's theory withstands precision scrutiny. In summary, my program will provide novel techniques and key results that will enable foundational investigations in physics through GW precision data.
Summary
The nascent field of gravitational wave (GW) science will be an interdisciplinary subject, enriching different branches of physics, yet the associated computational challenges are enormous. Faithful theoretical templates are a compulsory ingredient for successful data analysis and reliable physical interpretation of the signals. This is critical, for instance, to study the equation of state of neutron stars, the nature of black holes, and binary formation channels. However, while current templates for compact binary sources may be sufficient for detection and crude parameter estimation, they are too coarse for precision physics with GW data. We then find ourselves in a situation in which, for key processes within empirical reach, theoretical uncertainties may dominate. To move forward, profiting the most from GW observations, more accurate waveforms will be needed.
I have played a pioneering role in the development and implementation of a new formalism, known as the ‘effective field theory approach’, which has been instrumental for the construction of the state-of-the-art GW template bank. The goal of my proposal is thus to redefine the frontiers of analytic understanding in gravity through the effective field theory framework. Even more ambitiously, to go beyond the current computational paradigm with powerful tools which have been crucial for `new-physics' searches at the Large Hadron Collider.
The impact of the high-accuracy calculations I propose to undertake will be immense: from probes of dynamical spacetime and strongly interacting matter, to the potential to discover exotic compact objects and ultra-light particles in nature. Furthermore, GW observations scan gravity in a regime which is otherwise unexplored. Consequently, the coming decade will tell whether Einstein's theory withstands precision scrutiny. In summary, my program will provide novel techniques and key results that will enable foundational investigations in physics through GW precision data.
Max ERC Funding
1 975 000 €
Duration
Start date: 2019-06-01, End date: 2024-05-31
