Project acronym AlCat
Project Bond activation and catalysis with low-valent aluminium
Researcher (PI) Michael James COWLEY
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Country United Kingdom
Call Details Starting Grant (StG), PE5, ERC-2016-STG
Summary This project will develop the principles required to enable bond-modifying redox catalysis based on aluminium by preparing and studying new Al(I) compounds capable of reversible oxidative addition.
Catalytic processes are involved in the synthesis of 75 % of all industrially produced chemicals, but most catalysts involved are based on precious metals such as rhodium, palladium or platinum. These metals are expensive and their supply limited and unstable; there is a significant need to develop the chemistry of non-precious metals as alternatives. On toxicity and abundance alone, aluminium is an attractive candidate. Furthermore, recent work, including in our group, has demonstrated that Al(I) compounds can perform a key step in catalytic cycles - the oxidative addition of E-H bonds.
In order to realise the significant potential of Al(I) for transition-metal style catalysis we urgently need to:
- establish the principles governing oxidative addition and reductive elimination reactivity in aluminium systems.
- know how the reactivity of Al(I) compounds can be controlled by varying properties of ligand frameworks.
- understand the onward reactivity of oxidative addition products of Al(I) to enable applications in catalysis.
In this project we will:
- Study mechanisms of oxidative addition and reductive elimination of a range of synthetically relevant bonds at Al(I) centres, establishing the principles governing this fundamental reactivity.
- Develop new ligand frameworks to support of Al(I) centres and evaluate the effect of the ligand on oxidative addition/reductive elimination at Al centres.
- Investigate methods for Al-mediated functionalisation of organic compounds by exploring the reactivity of E-H oxidative addition products with unsaturated organic compounds.
Summary
This project will develop the principles required to enable bond-modifying redox catalysis based on aluminium by preparing and studying new Al(I) compounds capable of reversible oxidative addition.
Catalytic processes are involved in the synthesis of 75 % of all industrially produced chemicals, but most catalysts involved are based on precious metals such as rhodium, palladium or platinum. These metals are expensive and their supply limited and unstable; there is a significant need to develop the chemistry of non-precious metals as alternatives. On toxicity and abundance alone, aluminium is an attractive candidate. Furthermore, recent work, including in our group, has demonstrated that Al(I) compounds can perform a key step in catalytic cycles - the oxidative addition of E-H bonds.
In order to realise the significant potential of Al(I) for transition-metal style catalysis we urgently need to:
- establish the principles governing oxidative addition and reductive elimination reactivity in aluminium systems.
- know how the reactivity of Al(I) compounds can be controlled by varying properties of ligand frameworks.
- understand the onward reactivity of oxidative addition products of Al(I) to enable applications in catalysis.
In this project we will:
- Study mechanisms of oxidative addition and reductive elimination of a range of synthetically relevant bonds at Al(I) centres, establishing the principles governing this fundamental reactivity.
- Develop new ligand frameworks to support of Al(I) centres and evaluate the effect of the ligand on oxidative addition/reductive elimination at Al centres.
- Investigate methods for Al-mediated functionalisation of organic compounds by exploring the reactivity of E-H oxidative addition products with unsaturated organic compounds.
Max ERC Funding
1 493 679 €
Duration
Start date: 2017-03-01, End date: 2022-08-31
Project acronym BEAM-EDM
Project Unique Method for a Neutron Electric Dipole Moment Search using a Pulsed Beam
Researcher (PI) Florian Michael PIEGSA
Host Institution (HI) UNIVERSITAET BERN
Country Switzerland
Call Details Starting Grant (StG), PE2, ERC-2016-STG
Summary My research encompasses the application of novel methods and strategies in the field of low energy particle physics. The goal of the presented program is to lead an independent and highly competitive experiment to search for a CP violating neutron electric dipole moment (nEDM), as well as for new exotic interactions using highly sensitive neutron and proton spin resonance techniques.
The measurement of the nEDM is considered to be one of the most important fundamental physics experiments at low energy. It represents a promising route for finding new physics beyond the standard model (SM) and describes an important search for new sources of CP violation in order to understand the observed large baryon asymmetry in our universe. The main project will follow a novel concept based on my original idea, which plans to employ a pulsed neutron beam at high intensity instead of the established use of storable ultracold neutrons. This complementary and potentially ground-breaking method provides the possibility to distinguish between the signal due to a nEDM and previously limiting systematic effects, and should lead to an improved result compared to the present best nEDM beam experiment. The findings of these investigations will be of paramount importance and will form the cornerstone for the success of the full-scale experiment intended for the European Spallation Source. A second scientific question will be addressed by performing spin precession experiments searching for exotic short-range interactions and associated light bosons. This is a vivid field of research motivated by various extensions to the SM. The goal of these measurements, using neutrons and protons, is to search for additional interactions such new bosons mediate between ordinary particles.
Both topics describe ambitious and unique efforts. They use related techniques, address important questions in fundamental physics, and have the potential of substantial scientific implications and high-impact results.
Summary
My research encompasses the application of novel methods and strategies in the field of low energy particle physics. The goal of the presented program is to lead an independent and highly competitive experiment to search for a CP violating neutron electric dipole moment (nEDM), as well as for new exotic interactions using highly sensitive neutron and proton spin resonance techniques.
The measurement of the nEDM is considered to be one of the most important fundamental physics experiments at low energy. It represents a promising route for finding new physics beyond the standard model (SM) and describes an important search for new sources of CP violation in order to understand the observed large baryon asymmetry in our universe. The main project will follow a novel concept based on my original idea, which plans to employ a pulsed neutron beam at high intensity instead of the established use of storable ultracold neutrons. This complementary and potentially ground-breaking method provides the possibility to distinguish between the signal due to a nEDM and previously limiting systematic effects, and should lead to an improved result compared to the present best nEDM beam experiment. The findings of these investigations will be of paramount importance and will form the cornerstone for the success of the full-scale experiment intended for the European Spallation Source. A second scientific question will be addressed by performing spin precession experiments searching for exotic short-range interactions and associated light bosons. This is a vivid field of research motivated by various extensions to the SM. The goal of these measurements, using neutrons and protons, is to search for additional interactions such new bosons mediate between ordinary particles.
Both topics describe ambitious and unique efforts. They use related techniques, address important questions in fundamental physics, and have the potential of substantial scientific implications and high-impact results.
Max ERC Funding
1 404 062 €
Duration
Start date: 2017-04-01, End date: 2022-03-31
Project acronym CALCEAM
Project Cooperative Acceptor Ligands for Catalysis with Earth-Abundant Metals
Researcher (PI) Marc-Etienne Moret
Host Institution (HI) UNIVERSITEIT UTRECHT
Country Netherlands
Call Details Starting Grant (StG), PE5, ERC-2016-STG
Summary Homogeneous catalysis is of prime importance for the selective synthesis of high added value chemicals. Many of the currently available catalysts rely on noble metals (Ru, Os, Rh, Ir, Pd, Pt), which suffer from a high toxicity and environmental impact in addition to their high cost, calling for the development of new systems based on first-row transition metals (Mn, Fe, Co, Ni, Cu). The historical paradigm for catalyst design, i.e. one or more donor ligands giving electron density to stabilize a metal center and tune its reactivity, is currently being challenged by the development of acceptor ligands that mostly withdraw electron density from the metal center upon binding. In the last decade, such ligands – mostly based on boron and heavier main-group elements – have evolved from a structural curiosity to a powerful tool in designing new reactive units for homogeneous catalysis.
I will develop a novel class of ligands that use C=E (E=O, S, NR) multiple bonds anchored in close proximity to the metal by phosphine tethers. The electrophilic C=E multiple bond is designed to act as an acceptor moiety that adapts its binding mode to the electronic structure of reactive intermediates with the unique additional possibility of involving the lone pairs on heteroelement E in cooperative reactivity. Building on preliminary results showing that a C=O bond can function as a hemilabile ligand in a catalytic cycle, I will undertake a systematic, experimental and theoretical investigation of the structure and reactivity of M–C–E three membered rings formed by side-on coordination of C=E bonds to a first-row metal. Their ability to facilitate multi-electron transformations (oxidative addition, atom/group transfer reactions) will be investigated. In particular, hemilability of the C=E bond is expected to facilitate challenging C–C bond forming reactions mediated by Fe and Ni. This approach will demonstrate a new conceptual tool for the design of efficient base-metal catalysts.
Summary
Homogeneous catalysis is of prime importance for the selective synthesis of high added value chemicals. Many of the currently available catalysts rely on noble metals (Ru, Os, Rh, Ir, Pd, Pt), which suffer from a high toxicity and environmental impact in addition to their high cost, calling for the development of new systems based on first-row transition metals (Mn, Fe, Co, Ni, Cu). The historical paradigm for catalyst design, i.e. one or more donor ligands giving electron density to stabilize a metal center and tune its reactivity, is currently being challenged by the development of acceptor ligands that mostly withdraw electron density from the metal center upon binding. In the last decade, such ligands – mostly based on boron and heavier main-group elements – have evolved from a structural curiosity to a powerful tool in designing new reactive units for homogeneous catalysis.
I will develop a novel class of ligands that use C=E (E=O, S, NR) multiple bonds anchored in close proximity to the metal by phosphine tethers. The electrophilic C=E multiple bond is designed to act as an acceptor moiety that adapts its binding mode to the electronic structure of reactive intermediates with the unique additional possibility of involving the lone pairs on heteroelement E in cooperative reactivity. Building on preliminary results showing that a C=O bond can function as a hemilabile ligand in a catalytic cycle, I will undertake a systematic, experimental and theoretical investigation of the structure and reactivity of M–C–E three membered rings formed by side-on coordination of C=E bonds to a first-row metal. Their ability to facilitate multi-electron transformations (oxidative addition, atom/group transfer reactions) will be investigated. In particular, hemilability of the C=E bond is expected to facilitate challenging C–C bond forming reactions mediated by Fe and Ni. This approach will demonstrate a new conceptual tool for the design of efficient base-metal catalysts.
Max ERC Funding
1 500 000 €
Duration
Start date: 2017-08-01, End date: 2022-07-31
Project acronym CAVEHEART
Project Heart regeneration in the Mexican cavefish: The difference between healing and scarring
Researcher (PI) Mathilda MOMMERSTEEG
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country United Kingdom
Call Details Starting Grant (StG), LS4, ERC-2016-STG
Summary Whereas the human heart cannot regenerate cardiac muscle after myocardial infarction, certain fish efficiently repair their hearts. Astyanax mexicanus, a close relative of the zebrafish, is a single fish species comprising cave-dwelling and surface river populations. Remarkably, while surface fish regenerate their heart after injury, cavefish cannot and form a permanent fibrotic scar, similar to the human heart. Using transcriptomics analysis and immunohistochemistry, we have identified key differences in the scarring and inflammatory response between the surface and cavefish heart after injury. These differences include extracellular matrix (ECM) proteins, growth factors and macrophage populations present in one, but not the other population, suggesting properties unique to the surface fish scar that promote heart regeneration. The objective of the proposed project is to characterise and utilise these findings to identify therapeutic targets to heal the human heart after myocardial infarction. First, we will analyse the identified differences in scarring and immune response between the fish in detail, before testing the role of the most interesting proteins and macrophage populations during regeneration using CRISPR mutagenesis and clodronate liposomes. Next, we will link the key scarring and inflammatory differences directly to both the genome and the ability for heart regeneration using new and prior Quantitative Trait Loci analyses. This will allow to find the most fundamental molecular mechanisms directing the wound healing process towards regeneration versus scarring. Together with an in vitro and in vivo small molecule screen directed specifically at influencing scarring towards a more ‘fish-like’ regenerative phenotype in the cavefish and mouse heart after injury, this will provide targets for therapeutic strategies to maximise the endogenous regenerative potential of the mammalian heart, with the aim to find a cure for myocardial infarction.
Summary
Whereas the human heart cannot regenerate cardiac muscle after myocardial infarction, certain fish efficiently repair their hearts. Astyanax mexicanus, a close relative of the zebrafish, is a single fish species comprising cave-dwelling and surface river populations. Remarkably, while surface fish regenerate their heart after injury, cavefish cannot and form a permanent fibrotic scar, similar to the human heart. Using transcriptomics analysis and immunohistochemistry, we have identified key differences in the scarring and inflammatory response between the surface and cavefish heart after injury. These differences include extracellular matrix (ECM) proteins, growth factors and macrophage populations present in one, but not the other population, suggesting properties unique to the surface fish scar that promote heart regeneration. The objective of the proposed project is to characterise and utilise these findings to identify therapeutic targets to heal the human heart after myocardial infarction. First, we will analyse the identified differences in scarring and immune response between the fish in detail, before testing the role of the most interesting proteins and macrophage populations during regeneration using CRISPR mutagenesis and clodronate liposomes. Next, we will link the key scarring and inflammatory differences directly to both the genome and the ability for heart regeneration using new and prior Quantitative Trait Loci analyses. This will allow to find the most fundamental molecular mechanisms directing the wound healing process towards regeneration versus scarring. Together with an in vitro and in vivo small molecule screen directed specifically at influencing scarring towards a more ‘fish-like’ regenerative phenotype in the cavefish and mouse heart after injury, this will provide targets for therapeutic strategies to maximise the endogenous regenerative potential of the mammalian heart, with the aim to find a cure for myocardial infarction.
Max ERC Funding
1 499 429 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym Chi2-Nano-Oxides
Project Second-Order Nano-Oxides for Enhanced Nonlinear Photonics
Researcher (PI) Rachel GRANGE RODUIT
Host Institution (HI) EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Country Switzerland
Call Details Starting Grant (StG), PE5, ERC-2016-STG
Summary Nonlinear optics is present in our daily life with applications, e.g. light sources for microsurgery or green laser pointer. All of them use bulk materials such as glass fibers or crystals. Generating nonlinear effects from materials at the nanoscale would expand the applications to biology as imaging markers or optoelectronic integrated devices. However, nonlinear signals scale with the volume of a material. Therefore finding materials with high nonlinearities to avoid using high power and large interaction length is challenging. Many studies focus on third order nonlinearities (described by a χ(3) tensor) present in every material (silicon, graphene…) or on metals for enhancing nonlinearities with plasmonics. My approach is to explore second-order χ(2) nanomaterials, since they show higher nonlinearities than χ(3) ones, additional properties such as birefringence, wide band gap for transparency, high refractive index (n>2), and no ohmic losses. Typical χ(2) materials are oxides (BaTiO3, LiNbO3…) with a non-centrosymmetric crystal used for wavelength conversion like in second-harmonic generation (SHG).
The key idea is to demonstrate original strategies to enhance SHG of χ(2) nano-oxides with the material itself and without involving any hybrid effects from other materials such as plasmonic resonances of metals. First, I propose to use multiple Mie resonances from BaTiO3 nanoparticles to boost SHG in the UV to NIR range. Up to now, Mie effects at the nanoscale have been measured in materials with no χ(2) nonlinearities (silicon spheres). Second, since χ(2) oxides are difficult to etch, I will overcome this fabrication issue by demonstrating solution processed imprint lithography to form high-quality photonic crystal cavities from nanoparticles. Third, I will use facet processing of single LiNbO3 nanowire to obtain directionality effects for spectroscopy on-a-chip. This work fosters applications and commercial devices offering a sustainable future to this field.
Summary
Nonlinear optics is present in our daily life with applications, e.g. light sources for microsurgery or green laser pointer. All of them use bulk materials such as glass fibers or crystals. Generating nonlinear effects from materials at the nanoscale would expand the applications to biology as imaging markers or optoelectronic integrated devices. However, nonlinear signals scale with the volume of a material. Therefore finding materials with high nonlinearities to avoid using high power and large interaction length is challenging. Many studies focus on third order nonlinearities (described by a χ(3) tensor) present in every material (silicon, graphene…) or on metals for enhancing nonlinearities with plasmonics. My approach is to explore second-order χ(2) nanomaterials, since they show higher nonlinearities than χ(3) ones, additional properties such as birefringence, wide band gap for transparency, high refractive index (n>2), and no ohmic losses. Typical χ(2) materials are oxides (BaTiO3, LiNbO3…) with a non-centrosymmetric crystal used for wavelength conversion like in second-harmonic generation (SHG).
The key idea is to demonstrate original strategies to enhance SHG of χ(2) nano-oxides with the material itself and without involving any hybrid effects from other materials such as plasmonic resonances of metals. First, I propose to use multiple Mie resonances from BaTiO3 nanoparticles to boost SHG in the UV to NIR range. Up to now, Mie effects at the nanoscale have been measured in materials with no χ(2) nonlinearities (silicon spheres). Second, since χ(2) oxides are difficult to etch, I will overcome this fabrication issue by demonstrating solution processed imprint lithography to form high-quality photonic crystal cavities from nanoparticles. Third, I will use facet processing of single LiNbO3 nanowire to obtain directionality effects for spectroscopy on-a-chip. This work fosters applications and commercial devices offering a sustainable future to this field.
Max ERC Funding
1 500 000 €
Duration
Start date: 2017-02-01, End date: 2022-01-31
Project acronym COLGENES
Project Defining novel mechanisms critical for colorectal tumourigenesis
Researcher (PI) Kevin Brian MYANT
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Country United Kingdom
Call Details Starting Grant (StG), LS4, ERC-2016-STG
Summary Cancer genome sequencing has led to a paradigm shift in our understanding of oncogenesis. It has identified thousands of genetic alterations that segregate into two groups, a small number of frequently mutated genes and a much larger number of infrequently mutated genes. The causative role of frequently mutated genes is often clear and are the focus of concerted therapeutic development efforts. The role of those infrequently mutated is often unclear and can be difficult to separate from ‘mutational noise’. Determining the relevance of low frequency mutations is important for providing a full understanding of processes driving tumourigenesis and if functionally relevant may have broader implications on the applicability of targeted therapies.
This project aims to begin addressing this by defining the function of all genes mutated in colorectal cancer (CRC) in the earliest stages of tumour formation. I have performed a whole genome screen in a 3D organoid CRC initiation model identifying several potentially important mediators of this process. Crucially, some of these genes are mutated in CRC at low frequency but not described as cancer driver genes. Thus, I hypothesize that rather than ‘mutational noise’ infrequently mutated genes contribute to CRC initiation. I will test this by addressing two aims:
1) Determine the role of genes mutated in CRC during tumour initiation
2) Validate and determine the function of a subset of identified genes potentially defining novel cancer mechanisms
I will use a combination of CRISPR genetic disruption in state-of-the-art 3D mouse and human organoid cultures and advanced mouse models to address these aims. This comprehensive approach will provide a foundation for understanding the importance of the entire spectrum of mutations in CRC and open new avenues of research into the function of these genes. More broadly, it has the potential to make a profound impact on how we think about tumourigenic mechanisms and cancer therapeutics.
Summary
Cancer genome sequencing has led to a paradigm shift in our understanding of oncogenesis. It has identified thousands of genetic alterations that segregate into two groups, a small number of frequently mutated genes and a much larger number of infrequently mutated genes. The causative role of frequently mutated genes is often clear and are the focus of concerted therapeutic development efforts. The role of those infrequently mutated is often unclear and can be difficult to separate from ‘mutational noise’. Determining the relevance of low frequency mutations is important for providing a full understanding of processes driving tumourigenesis and if functionally relevant may have broader implications on the applicability of targeted therapies.
This project aims to begin addressing this by defining the function of all genes mutated in colorectal cancer (CRC) in the earliest stages of tumour formation. I have performed a whole genome screen in a 3D organoid CRC initiation model identifying several potentially important mediators of this process. Crucially, some of these genes are mutated in CRC at low frequency but not described as cancer driver genes. Thus, I hypothesize that rather than ‘mutational noise’ infrequently mutated genes contribute to CRC initiation. I will test this by addressing two aims:
1) Determine the role of genes mutated in CRC during tumour initiation
2) Validate and determine the function of a subset of identified genes potentially defining novel cancer mechanisms
I will use a combination of CRISPR genetic disruption in state-of-the-art 3D mouse and human organoid cultures and advanced mouse models to address these aims. This comprehensive approach will provide a foundation for understanding the importance of the entire spectrum of mutations in CRC and open new avenues of research into the function of these genes. More broadly, it has the potential to make a profound impact on how we think about tumourigenic mechanisms and cancer therapeutics.
Max ERC Funding
1 498 618 €
Duration
Start date: 2017-08-01, End date: 2022-07-31
Project acronym COMPLEX
Project The Degradation of Complex Modern Polymeric Objects in Heritage Collections: A System Dynamics Approach
Researcher (PI) Katherine CURRAN
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Country United Kingdom
Call Details Starting Grant (StG), SH5, ERC-2016-STG
Summary By viewing a scientific problem through the lens of heritage, COMPLEX will create an entirely new cross-disciplinary vision for understanding and modelling polymer degradation and build a world leading research team studying the degradation of modern polymeric objects in collections. Rather than focussing on specific chemical or physical processes, as has been done in the past, COMPLEX will consider polymeric objects as almost akin to living organisms, and by using a system dynamics approach will model objects in their environments in a way that reflects their real complexity, with multiple, inter-connecting interactions between material properties and environmental parameters.
As a polymer chemist, this project has been inspired by my 4 years of experience in the field of heritage, in particular by experiencing the problems raised by the conservation of modern polymeric objects such as plastics. The development of modern polymers during the 19th and 20th centuries has changed history and society and they are a part of our material heritage that it is essential to conserve for future generations. However, these objects are at risk due to their instability and a lack of knowledge within the museum sector as to their degradation behaviour.
System dynamics models will be developed incorporating multiple chemical and physical interactions between the components of polymeric objects and environmental parameters such as relative humidity or light. These will be used to predict the degradation behaviour of objects over time, to identify key parameters that are correlated to object change and provide practical solutions for heritage professionals. Above all, COMPLEX will provide a new way of looking at polymer degradation, that can be applied across a wide range of fields, including medicine, waste management and industry.
Summary
By viewing a scientific problem through the lens of heritage, COMPLEX will create an entirely new cross-disciplinary vision for understanding and modelling polymer degradation and build a world leading research team studying the degradation of modern polymeric objects in collections. Rather than focussing on specific chemical or physical processes, as has been done in the past, COMPLEX will consider polymeric objects as almost akin to living organisms, and by using a system dynamics approach will model objects in their environments in a way that reflects their real complexity, with multiple, inter-connecting interactions between material properties and environmental parameters.
As a polymer chemist, this project has been inspired by my 4 years of experience in the field of heritage, in particular by experiencing the problems raised by the conservation of modern polymeric objects such as plastics. The development of modern polymers during the 19th and 20th centuries has changed history and society and they are a part of our material heritage that it is essential to conserve for future generations. However, these objects are at risk due to their instability and a lack of knowledge within the museum sector as to their degradation behaviour.
System dynamics models will be developed incorporating multiple chemical and physical interactions between the components of polymeric objects and environmental parameters such as relative humidity or light. These will be used to predict the degradation behaviour of objects over time, to identify key parameters that are correlated to object change and provide practical solutions for heritage professionals. Above all, COMPLEX will provide a new way of looking at polymer degradation, that can be applied across a wide range of fields, including medicine, waste management and industry.
Max ERC Funding
1 499 394 €
Duration
Start date: 2017-04-01, End date: 2022-03-31
Project acronym CONSTAMIS
Project Connecting Statistical Mechanics and Conformal Field Theory: an Ising Model Perspective
Researcher (PI) CLEMENT HONGLER
Host Institution (HI) ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Country Switzerland
Call Details Starting Grant (StG), PE1, ERC-2016-STG
Summary The developments of Statistical Mechanics and Quantum Field Theory are among the major achievements of the 20th century's science. During the second half of the century, these two subjects started to converge. In two dimensions, this resulted in a most remarkable chapter of mathematical physics: Conformal Field Theory (CFT) reveals deep structures allowing for extremely precise investigations, making such theories powerful building blocks of many subjects of mathematics and physics. Unfortunately, this convergence has remained non-rigorous, leaving most of the spectacular field-theoretic applications to Statistical Mechanics conjectural.
About 15 years ago, several mathematical breakthroughs shed new light on this picture. The development of SLE curves and discrete complex analysis has enabled one to connect various statistical mechanics models with conformally symmetric processes. Recently, major progress was made on a key statistical mechanics model, the Ising model: the connection with SLE was established, and many formulae predicted by CFT were proven.
Important advances towards connecting Statistical Mechanics and CFT now appear possible. This is the goal of this proposal, which is organized in three objectives:
(I) Build a deep correspondence between the Ising model and CFT: reveal clear links between the objects and structures arising in the Ising and CFT frameworks.
(II) Gather the insights of (I) to study new connections to CFT, particularly for minimal models, current algebras and parafermions.
(III) Combine (I) and (II) to go beyond conformal symmetry: link the Ising model with massive integrable field theories.
The aim is to build one of the first rigorous bridges between Statistical Mechanics and CFT. It will help to close the gap between physical derivations and mathematical theorems. By linking the deep structures of CFT to concrete models that are applicable in many subjects, it will be potentially useful to theoretical and applied scientists.
Summary
The developments of Statistical Mechanics and Quantum Field Theory are among the major achievements of the 20th century's science. During the second half of the century, these two subjects started to converge. In two dimensions, this resulted in a most remarkable chapter of mathematical physics: Conformal Field Theory (CFT) reveals deep structures allowing for extremely precise investigations, making such theories powerful building blocks of many subjects of mathematics and physics. Unfortunately, this convergence has remained non-rigorous, leaving most of the spectacular field-theoretic applications to Statistical Mechanics conjectural.
About 15 years ago, several mathematical breakthroughs shed new light on this picture. The development of SLE curves and discrete complex analysis has enabled one to connect various statistical mechanics models with conformally symmetric processes. Recently, major progress was made on a key statistical mechanics model, the Ising model: the connection with SLE was established, and many formulae predicted by CFT were proven.
Important advances towards connecting Statistical Mechanics and CFT now appear possible. This is the goal of this proposal, which is organized in three objectives:
(I) Build a deep correspondence between the Ising model and CFT: reveal clear links between the objects and structures arising in the Ising and CFT frameworks.
(II) Gather the insights of (I) to study new connections to CFT, particularly for minimal models, current algebras and parafermions.
(III) Combine (I) and (II) to go beyond conformal symmetry: link the Ising model with massive integrable field theories.
The aim is to build one of the first rigorous bridges between Statistical Mechanics and CFT. It will help to close the gap between physical derivations and mathematical theorems. By linking the deep structures of CFT to concrete models that are applicable in many subjects, it will be potentially useful to theoretical and applied scientists.
Max ERC Funding
998 005 €
Duration
Start date: 2017-03-01, End date: 2022-02-28
Project acronym DIMO6FIT
Project DIMO6FIT: Extending the Standard Model -- Global Fits of Optimal Variables in Diboson Production
Researcher (PI) Kristin LOHWASSER
Host Institution (HI) THE UNIVERSITY OF SHEFFIELD
Country United Kingdom
Call Details Starting Grant (StG), PE2, ERC-2016-STG
Summary The status quo of particle physics after the first data taking at the Large Hadron Collider is: a light Higgs particle has been discovered that is perfectly compatible with the electroweak Standard Model (SM). While this is undoubtedly a historic step in particle physics, it is not entirely satisfactory, as in its current state the SM leaves many questions unanswered.
If the Standard Model of today is just the low energy theory of more complex phenomena, then these phenomena will become manifest in modifications of the cross sections and differential distributions of known processes. These modifications can be described by higher dimensional operators, which are general extensions of the SM and can be tested using precision measurements of diboson production processes.
The DIMO6Fit project will focus on measuring those production processes most sensitive to the new physics effects, using innovative analysis techniques aimed at significantly reducing the debilitating limitations in current measurements. I will set up a novel combined global fit for determining the higher dimensional operators coherently based on the LHC measurements.
The full determination of the higher dimensional operators will be the first global precision test of general extensions to the SM. The ERC Starting Grant will make it possible to bring together a team that will conduct more efficient measurements then today at the ATLAS experiment, that will establish the framework for new precision tests, and will generate results of yet unforeseeable potential. With DIMO6FIT I will establish an exciting programme aiming at determining the higher dimensional operators, which will help uncover new physics and elucidate its nature. These novel studies will form a unique and significant contribution to the understanding of the fundamental interactions of known and possibly yet unknown particles.
Summary
The status quo of particle physics after the first data taking at the Large Hadron Collider is: a light Higgs particle has been discovered that is perfectly compatible with the electroweak Standard Model (SM). While this is undoubtedly a historic step in particle physics, it is not entirely satisfactory, as in its current state the SM leaves many questions unanswered.
If the Standard Model of today is just the low energy theory of more complex phenomena, then these phenomena will become manifest in modifications of the cross sections and differential distributions of known processes. These modifications can be described by higher dimensional operators, which are general extensions of the SM and can be tested using precision measurements of diboson production processes.
The DIMO6Fit project will focus on measuring those production processes most sensitive to the new physics effects, using innovative analysis techniques aimed at significantly reducing the debilitating limitations in current measurements. I will set up a novel combined global fit for determining the higher dimensional operators coherently based on the LHC measurements.
The full determination of the higher dimensional operators will be the first global precision test of general extensions to the SM. The ERC Starting Grant will make it possible to bring together a team that will conduct more efficient measurements then today at the ATLAS experiment, that will establish the framework for new precision tests, and will generate results of yet unforeseeable potential. With DIMO6FIT I will establish an exciting programme aiming at determining the higher dimensional operators, which will help uncover new physics and elucidate its nature. These novel studies will form a unique and significant contribution to the understanding of the fundamental interactions of known and possibly yet unknown particles.
Max ERC Funding
1 497 000 €
Duration
Start date: 2017-02-01, End date: 2022-07-31
Project acronym EnteroBariatric
Project Investigating Host-Microbial Interactions after Bariatric Surgery
Researcher (PI) Jia LI
Host Institution (HI) IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Country United Kingdom
Call Details Starting Grant (StG), LS4, ERC-2016-STG
Summary Obesity and related co-morbidities give rise to severe health and socioeconomic problems. Surgical treatment for obesity (bariatric surgery) is remarkably effective in the control of morbid obesity and rapid resolution of Type 2 Diabetes, and the number of such procedures is increasing rapidly in many obesity-prevalent countries. We, and others, have demonstrated that surgical interventions such as Roux-en-Y Gastric Bypass (RYGB) modulates gut hormone levels, induces systemic metabolic changes and results in the shift of the microbiome from Firmicutes to the Proteobacteria phylum. Although the gut microbiota have been implicated in the reduction of adiposity post-surgery, the long-term effect of altered gut microbiota on patients who have undergone RYGB, remains to be studied. Our recent data suggested that microbial activities are highly associated with inflammation and cancer. My research programme aims to investigate the RYGB-specific gut microbiota impacts on host physiology and colon cancer risk. To achieve this goal, I will employ a multidisciplinary approach that combines systems biology techniques with a bottom-up approach. This work will deliver phenotypic and mechanistic characterisation of the interplay between the host and the gut microbiota. The research findings will significantly contribute towards the understanding of fundamental molecular and cellular processes that are key in host and gut microbiota interactions. This will provide knowledge-based evidence of the gut microbial impact on human physiology, and has the potential to unravel novel prevention targets and promote a more thorough healthcare strategy for bariatric patients.
Summary
Obesity and related co-morbidities give rise to severe health and socioeconomic problems. Surgical treatment for obesity (bariatric surgery) is remarkably effective in the control of morbid obesity and rapid resolution of Type 2 Diabetes, and the number of such procedures is increasing rapidly in many obesity-prevalent countries. We, and others, have demonstrated that surgical interventions such as Roux-en-Y Gastric Bypass (RYGB) modulates gut hormone levels, induces systemic metabolic changes and results in the shift of the microbiome from Firmicutes to the Proteobacteria phylum. Although the gut microbiota have been implicated in the reduction of adiposity post-surgery, the long-term effect of altered gut microbiota on patients who have undergone RYGB, remains to be studied. Our recent data suggested that microbial activities are highly associated with inflammation and cancer. My research programme aims to investigate the RYGB-specific gut microbiota impacts on host physiology and colon cancer risk. To achieve this goal, I will employ a multidisciplinary approach that combines systems biology techniques with a bottom-up approach. This work will deliver phenotypic and mechanistic characterisation of the interplay between the host and the gut microbiota. The research findings will significantly contribute towards the understanding of fundamental molecular and cellular processes that are key in host and gut microbiota interactions. This will provide knowledge-based evidence of the gut microbial impact on human physiology, and has the potential to unravel novel prevention targets and promote a more thorough healthcare strategy for bariatric patients.
Max ERC Funding
1 499 091 €
Duration
Start date: 2017-08-01, End date: 2022-07-31
