Project acronym BBSG
Project Bosnian Bones, Spanish Ghosts: 'Transitional Justice' and the Legal Shaping of Memory after Two Modern Conflicts
Researcher (PI) Sarah Lynn Wastell (Born Haller)
Host Institution (HI) GOLDSMITHS' COLLEGE
Country United Kingdom
Call Details Starting Grant (StG), SH2, ERC-2009-StG
Summary The proposed research entails an ethnographic study of two contemporary cases of post-conflict reconciliation: one, the Bosnian case, where international intervention ended conflict in a stalemate and went on to instigate a decade-long process of transition; and the other, the Spanish case, where a nationally-contrived pact of silence introduced an overnight transition after Franco's death a pact now being broken nearly seventy years after the country's civil war concluded. Both societies witnessed massive violations of international humanitarian law. Both societies are presently exhuming, identifying and re-burying their dead. But their trajectories of transitional justice could not have been more different. This project will investigate how Law shapes cultural memories of wartime atrocity in these contrasting scenarios. How do criminal prosecutions, constitutional reforms, and international rights mechanisms, provide or obfuscate the scales into which histories of violent conflict are framed? Does the systematic re-structuring of legislative and judicial infrastructure stifle recognition of past abuses or does it create the conditions through which such pasts can be confronted? How does Law shape or inflect the cultural politics of memory and memorialisation? And most importantly, how should legal activity be weighted, prioritised and sequenced with other, extra-legal components of peace-building initiatives? The ultimate goal of this project will be to mobilise the findings from the two field-sites to suggest a more nuanced assessment of Law s place in transitional justice. Arguing that disparate historical, cultural and legal contexts require equally distinct approaches towards social healing, the research aims to produce a Post-Conflict Action Framework an architecture of questions and concerns, which, once answered, would point towards context-specific designs for transitional justice programmes in the future.
Summary
The proposed research entails an ethnographic study of two contemporary cases of post-conflict reconciliation: one, the Bosnian case, where international intervention ended conflict in a stalemate and went on to instigate a decade-long process of transition; and the other, the Spanish case, where a nationally-contrived pact of silence introduced an overnight transition after Franco's death a pact now being broken nearly seventy years after the country's civil war concluded. Both societies witnessed massive violations of international humanitarian law. Both societies are presently exhuming, identifying and re-burying their dead. But their trajectories of transitional justice could not have been more different. This project will investigate how Law shapes cultural memories of wartime atrocity in these contrasting scenarios. How do criminal prosecutions, constitutional reforms, and international rights mechanisms, provide or obfuscate the scales into which histories of violent conflict are framed? Does the systematic re-structuring of legislative and judicial infrastructure stifle recognition of past abuses or does it create the conditions through which such pasts can be confronted? How does Law shape or inflect the cultural politics of memory and memorialisation? And most importantly, how should legal activity be weighted, prioritised and sequenced with other, extra-legal components of peace-building initiatives? The ultimate goal of this project will be to mobilise the findings from the two field-sites to suggest a more nuanced assessment of Law s place in transitional justice. Arguing that disparate historical, cultural and legal contexts require equally distinct approaches towards social healing, the research aims to produce a Post-Conflict Action Framework an architecture of questions and concerns, which, once answered, would point towards context-specific designs for transitional justice programmes in the future.
Max ERC Funding
1 420 000 €
Duration
Start date: 2009-09-01, End date: 2013-08-31
Project acronym BrainNanoFlow
Project Nanoscale dynamics in the extracellular space of the brain in vivo
Researcher (PI) Juan Alberto VARELA
Host Institution (HI) THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Country United Kingdom
Call Details Starting Grant (StG), LS5, ERC-2018-STG
Summary Aggregates of proteins such as amyloid-beta and alpha-synuclein circulate the extracellular space of the brain (ECS) and are thought to be key players in the development of neurodegenerative diseases. The clearance of these aggregates (among other toxic metabolites) is a fundamental physiological feature of the brain which is poorly understood due to the lack of techniques to study the nanoscale organisation of the ECS. Exciting advances in this field have recently shown that clearance is enhanced during sleep due to a major volume change in the ECS, facilitating the flow of the interstitial fluid. However, this process has only been characterised at a low spatial resolution while the physiological changes occur at the nanoscale. The recently proposed “glymphatic” pathway still remains controversial, as there are no techniques capable of distinguishing between diffusion and bulk flow in the ECS of living animals. Understanding these processes at a higher spatial resolution requires the development of single-molecule imaging techniques that can study the brain in living animals. Taking advantage of the strategies I have recently developed to target single-molecules in the brain in vivo with nanoparticles, we will do “nanoscopy” in living animals. Our proposal will test the glymphatic pathway at the spatial scale in which events happen, and explore how sleep and wake cycles alter the ECS and the diffusion of receptors in neuronal plasma membrane. Overall, BrainNanoFlow aims to understand how nanoscale changes in the ECS facilitate clearance of protein aggregates. We will also provide new insights to the pathological consequences of impaired clearance, focusing on the interactions between these aggregates and their putative receptors. Being able to perform single-molecule studies in vivo in the brain will be a major breakthrough in neurobiology, making possible the study of physiological and pathological processes that cannot be studied in simpler brain preparations.
Summary
Aggregates of proteins such as amyloid-beta and alpha-synuclein circulate the extracellular space of the brain (ECS) and are thought to be key players in the development of neurodegenerative diseases. The clearance of these aggregates (among other toxic metabolites) is a fundamental physiological feature of the brain which is poorly understood due to the lack of techniques to study the nanoscale organisation of the ECS. Exciting advances in this field have recently shown that clearance is enhanced during sleep due to a major volume change in the ECS, facilitating the flow of the interstitial fluid. However, this process has only been characterised at a low spatial resolution while the physiological changes occur at the nanoscale. The recently proposed “glymphatic” pathway still remains controversial, as there are no techniques capable of distinguishing between diffusion and bulk flow in the ECS of living animals. Understanding these processes at a higher spatial resolution requires the development of single-molecule imaging techniques that can study the brain in living animals. Taking advantage of the strategies I have recently developed to target single-molecules in the brain in vivo with nanoparticles, we will do “nanoscopy” in living animals. Our proposal will test the glymphatic pathway at the spatial scale in which events happen, and explore how sleep and wake cycles alter the ECS and the diffusion of receptors in neuronal plasma membrane. Overall, BrainNanoFlow aims to understand how nanoscale changes in the ECS facilitate clearance of protein aggregates. We will also provide new insights to the pathological consequences of impaired clearance, focusing on the interactions between these aggregates and their putative receptors. Being able to perform single-molecule studies in vivo in the brain will be a major breakthrough in neurobiology, making possible the study of physiological and pathological processes that cannot be studied in simpler brain preparations.
Max ERC Funding
1 552 948 €
Duration
Start date: 2018-12-01, End date: 2023-11-30
Project acronym CEAD
Project Contextualizing Evidence for Action on Diabetes in low-resource Settings: A mixed-methods case study in Quito and Esmeraldas, Ecuador.
Researcher (PI) Lucy Anne Parker
Host Institution (HI) UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Country Spain
Call Details Starting Grant (StG), SH3, ERC-2018-STG
Summary The relentless rise in diabetes is one of the greatest global health emergencies of the 21st century. The increase is most pronounced in low and middle income countries where today three quarters of people with diabetes live and over 80% of the deaths attributed to non-communicable diseases occur. In light of the wealth of knowledge already available about how to tackle the problem, most major international organizations call for the adoption healthy public policies and initiatives to strengthening health systems. However, implementation of recommended action remains limited in many settings. Most evidence comes from high-income settings and may generate recommendations that cannot be successfully implemented in other settings without careful consideration and contextualization. I propose here that this “know-do” gap can be reduced by revealing the barriers to implementing evidence-based recommendations, engaging local stakeholders in developing context-led innovations and developing a tool-kit for contextualizing and implementing diabetes recommendations in low-resource settings. I plan the research in two carefully selected settings in Ecuador, with mixed-methods combining quantitative epidemiological research and qualitative methodology to generate the rich and varied knowledge that is required to trigger policy action and/or changes in care models. Furthermore, I will engage patients, community members, health workers and decision makers in the process of knowledge generation, interpretation and use. The overarching objective is hence, to explore the process by which global recommendations can be translated into context-specific, evidence-informed action for diabetes prevention in low-resource settings. The findings will support the global endeavour to bridge the global “know-do” gap, one of the most important public health challenges this century and a great opportunity for strengthening health systems and achieving health equity.
Summary
The relentless rise in diabetes is one of the greatest global health emergencies of the 21st century. The increase is most pronounced in low and middle income countries where today three quarters of people with diabetes live and over 80% of the deaths attributed to non-communicable diseases occur. In light of the wealth of knowledge already available about how to tackle the problem, most major international organizations call for the adoption healthy public policies and initiatives to strengthening health systems. However, implementation of recommended action remains limited in many settings. Most evidence comes from high-income settings and may generate recommendations that cannot be successfully implemented in other settings without careful consideration and contextualization. I propose here that this “know-do” gap can be reduced by revealing the barriers to implementing evidence-based recommendations, engaging local stakeholders in developing context-led innovations and developing a tool-kit for contextualizing and implementing diabetes recommendations in low-resource settings. I plan the research in two carefully selected settings in Ecuador, with mixed-methods combining quantitative epidemiological research and qualitative methodology to generate the rich and varied knowledge that is required to trigger policy action and/or changes in care models. Furthermore, I will engage patients, community members, health workers and decision makers in the process of knowledge generation, interpretation and use. The overarching objective is hence, to explore the process by which global recommendations can be translated into context-specific, evidence-informed action for diabetes prevention in low-resource settings. The findings will support the global endeavour to bridge the global “know-do” gap, one of the most important public health challenges this century and a great opportunity for strengthening health systems and achieving health equity.
Max ERC Funding
1 475 334 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym CLD
Project China, Law, and Development
Researcher (PI) Matthew ERIE
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country United Kingdom
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Summary
The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo/Euro/American approaches to “law and development” (LD). Whereas LD orthodoxy has sought to improve legal institutions in poor states, Chinese do not foster rule of law abroad. Instead, Chinese view law as one set of rules, among others, to facilitate economic transactions and not to foster democratization. This distinction has sparked a global debate about the so-called “China model” as an alternative to LD. Yet there is little empirical data with which to assess the means and ends of China’s expanded footprint, a question with long-term implications for much of the developing world. This project addresses that problem by proposing that even if Chinese cross-border development does not operate through transparent rules, it nonetheless has its own notion of order. The project adopts a multi-sited, mixed method, and interdisciplinary approach—at the intersection of comparative law, developmental studies, and legal anthropology—to understand the nature of China’s order. The project has two objectives:
1. To establish the conceptual bases for the study of China’s approach to law and development by developing the first systematic study of the impacts of Chinese investment on the legal systems of developing economies.
2. To experiment with a comparative research design to theorize how China’s approach suggests a type of order that extends through a conjuncture of regional and local processes and manifests itself differently in diverse contexts.
Max ERC Funding
1 499 381 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym DCFM
Project Default and Collateral in Financial Markets
Researcher (PI) Ioannis Vailakis
Host Institution (HI) THE UNIVERSITY OF EXETER
Country United Kingdom
Call Details Starting Grant (StG), SH1, ERC-2009-StG
Summary The main objective of this project is to research the economic implications of default and collateral in financial markets. It is motivated from the observation that much of the lending in modern economies is secured by some form of collateral and by the empirical fact that modern economies experience a substantial amount of default and bankruptcy. From a theoretical perspective, the research aims to explore new ways of modelling default and collateral and employ them to evaluate the impact of default and collateral on market outcomes. From a policy recommendation perspective, the research aims to develop models with testable implications that can be used by practitioners to discuss the consequences of a wide range of policies. In particular, to explore which kind of regulation procedures should be implemented in order to lower the risk of default and at the same time not to reduce too much risk-sharing. The agenda includes two research directions. The first research direction will focus on the implications of default and collateral in economies with bounded rational agents. Our aim is to understand how default and collateral affect market outcomes in environments where agents are allowed to have very divergent and therefore possibly incorrect beliefs about endogenous economic variables like future prices and delivery rates. The second research direction will focus on the implications of default and collateral in economies with an open ended horizon. Our aim is to investigate endogenous debt constraints that are compatible with equilibrium and simultaneously allow for as much risk sharing as possible.
Summary
The main objective of this project is to research the economic implications of default and collateral in financial markets. It is motivated from the observation that much of the lending in modern economies is secured by some form of collateral and by the empirical fact that modern economies experience a substantial amount of default and bankruptcy. From a theoretical perspective, the research aims to explore new ways of modelling default and collateral and employ them to evaluate the impact of default and collateral on market outcomes. From a policy recommendation perspective, the research aims to develop models with testable implications that can be used by practitioners to discuss the consequences of a wide range of policies. In particular, to explore which kind of regulation procedures should be implemented in order to lower the risk of default and at the same time not to reduce too much risk-sharing. The agenda includes two research directions. The first research direction will focus on the implications of default and collateral in economies with bounded rational agents. Our aim is to understand how default and collateral affect market outcomes in environments where agents are allowed to have very divergent and therefore possibly incorrect beliefs about endogenous economic variables like future prices and delivery rates. The second research direction will focus on the implications of default and collateral in economies with an open ended horizon. Our aim is to investigate endogenous debt constraints that are compatible with equilibrium and simultaneously allow for as much risk sharing as possible.
Max ERC Funding
156 538 €
Duration
Start date: 2010-06-01, End date: 2012-06-30
Project acronym DEMIG
Project The determinants of international migration: A theoretical and empirical assessment of policy, origin and destination effects
Researcher (PI) Hein Gysbert De Haas
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Country United Kingdom
Call Details Starting Grant (StG), SH3, ERC-2009-StG
Summary The main question of this research project is: how do migration policies of receiving and sending states affect the size, direction and nature of international migration to wealthy countries? The effectiveness of migration policies has been widely contested in the face of their apparent failure to steer immigration and their many unintended, perverse effects. Due to fundamental conceptual and methodological flaws, most empirical evidence has remained largely descriptive and biased by omitting crucial sending country and policy variables. This project answers this question by embedding the systematic empirical analysis of policy effects into a comprehensive theoretical framework of the macro and meso-level forces driving international migration to and from wealthy countries. This is achieved by linking separately evolved migration theories focusing on either sending or receiving countries and integrating them with theories on the internal dynamics of migration processes. A systematic review and categorisation of receiving and sending country migration policies will provide an improved operationalisation of policy variables. Subsequently, this framework will be subjected to quantitative empirical tests drawing on gross and bilateral (country-to-country) migration flow data, with a particular focus on Europe. Methodologically, this project is groundbreaking by introducing a longitudinal, double comparative approach by studying migration flows of multiple origin groups to multiple destination countries. This design enables a unique, simultaneous analysis of origin and destination country, network and policy effects. Theoretically, this research project is innovative by going beyond simple push-pull and equilibrium models and linking sending and receiving side, and economic and non-economic migration theory. This project is policy-relevant by improving insight in the way policies shape migration processes in their interaction with other migration determinants
Summary
The main question of this research project is: how do migration policies of receiving and sending states affect the size, direction and nature of international migration to wealthy countries? The effectiveness of migration policies has been widely contested in the face of their apparent failure to steer immigration and their many unintended, perverse effects. Due to fundamental conceptual and methodological flaws, most empirical evidence has remained largely descriptive and biased by omitting crucial sending country and policy variables. This project answers this question by embedding the systematic empirical analysis of policy effects into a comprehensive theoretical framework of the macro and meso-level forces driving international migration to and from wealthy countries. This is achieved by linking separately evolved migration theories focusing on either sending or receiving countries and integrating them with theories on the internal dynamics of migration processes. A systematic review and categorisation of receiving and sending country migration policies will provide an improved operationalisation of policy variables. Subsequently, this framework will be subjected to quantitative empirical tests drawing on gross and bilateral (country-to-country) migration flow data, with a particular focus on Europe. Methodologically, this project is groundbreaking by introducing a longitudinal, double comparative approach by studying migration flows of multiple origin groups to multiple destination countries. This design enables a unique, simultaneous analysis of origin and destination country, network and policy effects. Theoretically, this research project is innovative by going beyond simple push-pull and equilibrium models and linking sending and receiving side, and economic and non-economic migration theory. This project is policy-relevant by improving insight in the way policies shape migration processes in their interaction with other migration determinants
Max ERC Funding
1 186 768 €
Duration
Start date: 2010-01-01, End date: 2014-12-31
Project acronym EMPORIGIN
Project What are the origins of empathy? A comparative developmental investigation
Researcher (PI) Susanna Elizabeth Valerie CLAY
Host Institution (HI) UNIVERSITY OF DURHAM
Country United Kingdom
Call Details Starting Grant (StG), SH4, ERC-2018-STG
Summary Empathy – sharing and understanding others’ emotions and thoughts – is a defining feature of what it means to be human. However, we lack knowledge about the origins of empathy and to what extent its sub-components reflect species and cultural universals. Studying infants and great apes enables us to identify the developmental and evolutionary origins of empathy and the extent of its human uniqueness. Until now, it has largely been assumed that infants and great apes lack the capacity for empathy. However, this claim may reflect a lack of adequate methodologies and research attention, leaving infant and great ape empathy underestimated. Now, combining novel techniques to investigate empathy comparatively (thermal-imaging, pupillometry and eye-tracking) with longitudinal observations and innovative experiments, EMPORIGIN will overcome this issue to provide the first comparative investigation of empathy development in humans and bonobos, our closest living relatives. Rich datasets on bonobo (wild and semi-captive) infant development and caregiver interactions will be compared to those from human infants in two small-scale, traditional societies – Vanuatu and Samoa. Both societies show distributed-caregiving but vary in societal structure and emotional expressivity. Using a cross-species and cross-cultural approach, EMPORIGIN will deliver step-change insights into empathy development that go far beyond the State-of-the-Art. We will test the hypothesis that humans and bonobos share a core capacity for empathy, but humans diverge in a greater motivation to ameliorate others’ emotional states and a capacity for reciprocal emotional exchange. These capacities could lead to a cascade of human-unique forms of sharing and co-operation. Combining approaches across biology, psychology, ethology and anthropology, EMPORIGIN will advance our understanding of the origins of empathy, one of our most remarkable capacities, and challenge current perspectives about its human uniqueness.
Summary
Empathy – sharing and understanding others’ emotions and thoughts – is a defining feature of what it means to be human. However, we lack knowledge about the origins of empathy and to what extent its sub-components reflect species and cultural universals. Studying infants and great apes enables us to identify the developmental and evolutionary origins of empathy and the extent of its human uniqueness. Until now, it has largely been assumed that infants and great apes lack the capacity for empathy. However, this claim may reflect a lack of adequate methodologies and research attention, leaving infant and great ape empathy underestimated. Now, combining novel techniques to investigate empathy comparatively (thermal-imaging, pupillometry and eye-tracking) with longitudinal observations and innovative experiments, EMPORIGIN will overcome this issue to provide the first comparative investigation of empathy development in humans and bonobos, our closest living relatives. Rich datasets on bonobo (wild and semi-captive) infant development and caregiver interactions will be compared to those from human infants in two small-scale, traditional societies – Vanuatu and Samoa. Both societies show distributed-caregiving but vary in societal structure and emotional expressivity. Using a cross-species and cross-cultural approach, EMPORIGIN will deliver step-change insights into empathy development that go far beyond the State-of-the-Art. We will test the hypothesis that humans and bonobos share a core capacity for empathy, but humans diverge in a greater motivation to ameliorate others’ emotional states and a capacity for reciprocal emotional exchange. These capacities could lead to a cascade of human-unique forms of sharing and co-operation. Combining approaches across biology, psychology, ethology and anthropology, EMPORIGIN will advance our understanding of the origins of empathy, one of our most remarkable capacities, and challenge current perspectives about its human uniqueness.
Max ERC Funding
1 499 829 €
Duration
Start date: 2019-03-01, End date: 2024-02-29
Project acronym EXPC
Project Challenging and extending predictive coding as an account of brain function
Researcher (PI) Thomas FITZGERALD
Host Institution (HI) UNIVERSITY OF EAST ANGLIA
Country United Kingdom
Call Details Starting Grant (StG), SH4, ERC-2018-STG
Summary Probabilistic models of brain function, which propose that the brain can be understood as implementing the principles of optimal statistical inference, have become extremely influential in recent years. Predictive coding is perhaps the most widely held, and best supported, of these models, particularly within cognitive neuroscience. However, current models of predictive coding and its neuronal substrates are still relatively simple, and do not explain how humans solve a number of fundamental problems. This limits their power to explain brain function. I propose a series of experiments designed to test how human subjects address a number of these core problems. I will use behavioural and neuroimaging data to develop and test extensions to current models (or, if necessary, provide an alternative framework for understanding brain function). The purpose of this is two-fold, to give insight into the computations that underlie cognitive function, and to provide understanding of the neurobiological processes that support those computations. The project will thus constitute a stepping stone towards developing a mechanistic model of how the brain implements cognition.
Summary
Probabilistic models of brain function, which propose that the brain can be understood as implementing the principles of optimal statistical inference, have become extremely influential in recent years. Predictive coding is perhaps the most widely held, and best supported, of these models, particularly within cognitive neuroscience. However, current models of predictive coding and its neuronal substrates are still relatively simple, and do not explain how humans solve a number of fundamental problems. This limits their power to explain brain function. I propose a series of experiments designed to test how human subjects address a number of these core problems. I will use behavioural and neuroimaging data to develop and test extensions to current models (or, if necessary, provide an alternative framework for understanding brain function). The purpose of this is two-fold, to give insight into the computations that underlie cognitive function, and to provide understanding of the neurobiological processes that support those computations. The project will thus constitute a stepping stone towards developing a mechanistic model of how the brain implements cognition.
Max ERC Funding
1 464 713 €
Duration
Start date: 2019-01-01, End date: 2023-12-31
Project acronym FIDELIO
Project Forecasting social Impacts of bioDiversity consErvation poLicies In EurOpe
Researcher (PI) Nikoleta JONES
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Country United Kingdom
Call Details Starting Grant (StG), SH2, ERC-2018-STG
Summary Designating Protected Areas (PAs) is the most important policy tool for biodiversity conservation. Over 100 new PAs have been established in the past 36 months in European Union territory. However, effective management of PAs is often obstructed by conflicts mainly associated with the social impacts (SIs) imposed on local communities by their establishment. Despite the importance of these SIs there are certain aspects in this field that remain significantly under-researched. There is now an increasing need to incorporate SI assessments in decision making processes by providing a clear framework explaining how perceptions of these impacts are created and predicting their change in the future. This will support the achievement of international goals for biodiversity conservation and adaptation to climate change as well as better accounting for social justice issues for communities dependent on protected natural resources. The aim of FIDELIO is to develop for the first time a new paradigm in order to understand how perceptions of SIs are formulated taking into consideration the dimensions of space and time. FIDELIO will assist in increasing public engagement and the incorporation of local opinions in decision-making. It will also facilitate the process of policy development and a reduction in conflicts between different stakeholders in PAs. FIDELIO will last 5 years and its research objectives will be explored through the application of a mixed-methods approach including the implementation of two rounds of social surveys in 4 PAs across Europe and the testing of the framework in 15 additional PAs. This is an extremely timely project considering the steady increase of new PAs and the re-designation of current ones. FIDELIO will contribute to the better understanding of SIs and facilitate predictions for their change in the future, while assisting in maximizing social benefits for local communities arising from the designation of a PA.
Summary
Designating Protected Areas (PAs) is the most important policy tool for biodiversity conservation. Over 100 new PAs have been established in the past 36 months in European Union territory. However, effective management of PAs is often obstructed by conflicts mainly associated with the social impacts (SIs) imposed on local communities by their establishment. Despite the importance of these SIs there are certain aspects in this field that remain significantly under-researched. There is now an increasing need to incorporate SI assessments in decision making processes by providing a clear framework explaining how perceptions of these impacts are created and predicting their change in the future. This will support the achievement of international goals for biodiversity conservation and adaptation to climate change as well as better accounting for social justice issues for communities dependent on protected natural resources. The aim of FIDELIO is to develop for the first time a new paradigm in order to understand how perceptions of SIs are formulated taking into consideration the dimensions of space and time. FIDELIO will assist in increasing public engagement and the incorporation of local opinions in decision-making. It will also facilitate the process of policy development and a reduction in conflicts between different stakeholders in PAs. FIDELIO will last 5 years and its research objectives will be explored through the application of a mixed-methods approach including the implementation of two rounds of social surveys in 4 PAs across Europe and the testing of the framework in 15 additional PAs. This is an extremely timely project considering the steady increase of new PAs and the re-designation of current ones. FIDELIO will contribute to the better understanding of SIs and facilitate predictions for their change in the future, while assisting in maximizing social benefits for local communities arising from the designation of a PA.
Max ERC Funding
1 495 786 €
Duration
Start date: 2019-02-01, End date: 2024-01-31
Project acronym GENESFORCEMOTION
Project Physical Forces Driving Collective Cell Migration: from Genes to Mechanism
Researcher (PI) Xavier Trepat Guixer
Host Institution (HI) FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Country Spain
Call Details Starting Grant (StG), LS3, ERC-2009-StG
Summary Fundamental biological processes including morphogenesis, tissue repair, and tumour metastasis require collective cell motions, and to drive these motions cells exert traction forces on their surroundings. The mechanisms underlying this basic principle of health and disease have been debated intensively and, using a variety of methods in vivo, in vitro, and in silico, much conflicting evidence has accumulated. This conflicting evidence has been in every case indirect or inferential, however, because within the moving cell group the physical forces themselves have remained inaccessible to direct experimental observation. To fill this gap, this ERC application describes an interdisciplinary project to uncover the physical mechanisms underlying collective cell migration. In Objective 1, I propose to develop technology to map forces that cells within moving groups exert on each other and on their extracellular matrix. In Objective 2, we will use siRNA technology to provide a systematic analysis of the genes that regulate force generation and transmission in a migrating epithelial cell sheet. In Objective 3, we will use this pool of data to establish a constitutive link between genes, forces and collective cell motion. Although these Objectives present major technical and scientific challenges, the feasibility of each is supported by a unique technical know-how and by a productive track record in the field of cell biophysics.
Summary
Fundamental biological processes including morphogenesis, tissue repair, and tumour metastasis require collective cell motions, and to drive these motions cells exert traction forces on their surroundings. The mechanisms underlying this basic principle of health and disease have been debated intensively and, using a variety of methods in vivo, in vitro, and in silico, much conflicting evidence has accumulated. This conflicting evidence has been in every case indirect or inferential, however, because within the moving cell group the physical forces themselves have remained inaccessible to direct experimental observation. To fill this gap, this ERC application describes an interdisciplinary project to uncover the physical mechanisms underlying collective cell migration. In Objective 1, I propose to develop technology to map forces that cells within moving groups exert on each other and on their extracellular matrix. In Objective 2, we will use siRNA technology to provide a systematic analysis of the genes that regulate force generation and transmission in a migrating epithelial cell sheet. In Objective 3, we will use this pool of data to establish a constitutive link between genes, forces and collective cell motion. Although these Objectives present major technical and scientific challenges, the feasibility of each is supported by a unique technical know-how and by a productive track record in the field of cell biophysics.
Max ERC Funding
1 749 745 €
Duration
Start date: 2010-01-01, End date: 2014-12-31