Project acronym EyeRegen
Project Engineering a scaffold based therapy for corneal regeneration
Researcher (PI) Mark Joseph Ahearne
Host Institution (HI) THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Country Ireland
Call Details Starting Grant (StG), PE8, ERC-2014-STG
Summary Corneal blindness resulting from disease, physical injury or chemical burns affects millions worldwide and has a considerable economic and social impact on the lives of people across Europe. In many cases corneal transplants can restore vision however the shortage of donor corneas suitable for transplantation has necessitated the development of alternative treatments. The aim of this project is to develop a new approach to corneal tissue regeneration. Previous approaches at engineering corneal tissue have required access to donor cells and lengthy culture periods in an attempt to grow tissue in vitro prior to implantation with only limited success and at great expense. Our approach will differ fundamentally from these in that we will design artificial corneal scaffolds that do not require donated cells or in vitro culture but instead will recruit the patient’s own cells to regenerate the cornea post-implantation. These biomaterial scaffolds will incorporate specific chemical and physical cues with the deliberate aim of attracting cells and inducing tissue formation. Studies will be undertaken to examine how different chemical, biochemical, physical and mechanical cues can be used to control the behaviour of corneal epithelial, stromal and endothelial cells. Once the optimal combination of these cues has been determined, this information will be incorporated into the design of the scaffold. Recent advances in manufacturing and material processing technology will enable us to develop scaffolds with organized nanometric architectures and that incorporate controlled growth factor release mechanisms. Techniques such as 3D bio-printing and nanofiber electrospinning will be used to fabricate scaffolds. The ability of the scaffold to attract cells and promote matrix remodelling will be examined by developing an in vitro bioreactor system capable of mimicking the ocular environment and by performing in vivo tests using a live animal model.
Summary
Corneal blindness resulting from disease, physical injury or chemical burns affects millions worldwide and has a considerable economic and social impact on the lives of people across Europe. In many cases corneal transplants can restore vision however the shortage of donor corneas suitable for transplantation has necessitated the development of alternative treatments. The aim of this project is to develop a new approach to corneal tissue regeneration. Previous approaches at engineering corneal tissue have required access to donor cells and lengthy culture periods in an attempt to grow tissue in vitro prior to implantation with only limited success and at great expense. Our approach will differ fundamentally from these in that we will design artificial corneal scaffolds that do not require donated cells or in vitro culture but instead will recruit the patient’s own cells to regenerate the cornea post-implantation. These biomaterial scaffolds will incorporate specific chemical and physical cues with the deliberate aim of attracting cells and inducing tissue formation. Studies will be undertaken to examine how different chemical, biochemical, physical and mechanical cues can be used to control the behaviour of corneal epithelial, stromal and endothelial cells. Once the optimal combination of these cues has been determined, this information will be incorporated into the design of the scaffold. Recent advances in manufacturing and material processing technology will enable us to develop scaffolds with organized nanometric architectures and that incorporate controlled growth factor release mechanisms. Techniques such as 3D bio-printing and nanofiber electrospinning will be used to fabricate scaffolds. The ability of the scaffold to attract cells and promote matrix remodelling will be examined by developing an in vitro bioreactor system capable of mimicking the ocular environment and by performing in vivo tests using a live animal model.
Max ERC Funding
1 498 734 €
Duration
Start date: 2015-07-01, End date: 2020-12-31
Project acronym LITTLE TOOLS
Project Enacting the Good Economy: Biocapitalization and the little tools of valuation
Researcher (PI) Kristin Asdal
Host Institution (HI) UNIVERSITETET I OSLO
Country Norway
Call Details Starting Grant (StG), SH2, ERC-2014-STG
Summary What shall we live off in the future? Where will our food come from, and what will form the basis for our economies? A so-called “blue revolution”, where fish become farmed rather than caught, is increasingly presented as an answer to the above questions. This transformation of the economy exemplifies ongoing efforts to produce new forms of capital out of the ordering and reordering of life. These processes are intimately related to the expanding life sciences, the bioeconomy and what is sometimes called new forms of biocapital.
But how do such large transformations take place in actual practice, and by which means? This project argues that if we are to understand such major transformations we need to study “little tools”, that is, material-semiotic entities that carefully modify and work upon bodies, markets and science.
Emerging bioeconomies are expected not only to produce economic value but also to enact values in other ways that contribute to what this project refers to as “the good economy”. Such values include enabling sustainable fisheries, secure animal welfare or sustainable growth.
The main hypothesis of the current project is that the enactment of the good economy can be studied by valuation practices performed by material-semiotic little tools. The project will explore this hypothesis at multiple sites for biocapitalization: science, the market, policy and funding institutions. This project will focus on how these interact and encounter one another. The aim is twofold: first, to provide new empirical insights about how biocapitalization processes are enacted in practice and at strategic sites, using cross-disciplinary methods from actor-network theory, the humanities and economic sociology; second to contribute analytically and methodologically to the field of Science and Technology Studies (STS) by drawing on resources from economic sociology and the humanities in order to provide an analytical framework for comprehending biocapitalization practices.
Summary
What shall we live off in the future? Where will our food come from, and what will form the basis for our economies? A so-called “blue revolution”, where fish become farmed rather than caught, is increasingly presented as an answer to the above questions. This transformation of the economy exemplifies ongoing efforts to produce new forms of capital out of the ordering and reordering of life. These processes are intimately related to the expanding life sciences, the bioeconomy and what is sometimes called new forms of biocapital.
But how do such large transformations take place in actual practice, and by which means? This project argues that if we are to understand such major transformations we need to study “little tools”, that is, material-semiotic entities that carefully modify and work upon bodies, markets and science.
Emerging bioeconomies are expected not only to produce economic value but also to enact values in other ways that contribute to what this project refers to as “the good economy”. Such values include enabling sustainable fisheries, secure animal welfare or sustainable growth.
The main hypothesis of the current project is that the enactment of the good economy can be studied by valuation practices performed by material-semiotic little tools. The project will explore this hypothesis at multiple sites for biocapitalization: science, the market, policy and funding institutions. This project will focus on how these interact and encounter one another. The aim is twofold: first, to provide new empirical insights about how biocapitalization processes are enacted in practice and at strategic sites, using cross-disciplinary methods from actor-network theory, the humanities and economic sociology; second to contribute analytically and methodologically to the field of Science and Technology Studies (STS) by drawing on resources from economic sociology and the humanities in order to provide an analytical framework for comprehending biocapitalization practices.
Max ERC Funding
1 495 079 €
Duration
Start date: 2015-09-01, End date: 2020-12-31
Project acronym OscillatoryVision
Project The retinae as windows to the brain: An oscillatory vision
Researcher (PI) Sarang Suresh Dalal
Host Institution (HI) AARHUS UNIVERSITET
Country Denmark
Call Details Starting Grant (StG), SH4, ERC-2014-STG
Summary Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human visual processing:
1) Could variable retinal timing be linked to intrinsic image properties and pass on phase variance downstream to visual cortex? Our data suggests the retina responds to moving gratings and natural imagery with non-phase-locked high gamma oscillations (>65 Hz) just like visual cortex, and that slower ERG potentials exhibit strong phase-locking within stimuli but large phase variance across stimuli.
2) Do such retinal gamma band responses, both evoked and induced, directly drive some cortical gamma responses? Pilot data suggests that it can, through retinocortical coherence, our novel ERG-MEG mapping technique.
3) Several kinds of motion have now been shown to elicit massive synchrony in mammalian retina circuits. Does this also result in macroscopic high-frequency activity? If so, our experiments will finally reveal and characterize motion detection by the human retina.
4) Do efferent pathways to the retina exist in humans? We discovered that the ERG exhibits eyes-closed alpha waves strikingly similar to the classic EEG phenomenon and, leveraging our retinocortical coherence technique, that this activity is likely driven by contralateral occipital cortex. Then, can retinal responses be influenced by ongoing cortical activity?
Characterizing retinocortical interaction represents a complete paradigm shift that will be imperative for our understanding of neural synchrony in the human nervous system and enable several groundbreaking new avenues for research.
Summary
Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human visual processing:
1) Could variable retinal timing be linked to intrinsic image properties and pass on phase variance downstream to visual cortex? Our data suggests the retina responds to moving gratings and natural imagery with non-phase-locked high gamma oscillations (>65 Hz) just like visual cortex, and that slower ERG potentials exhibit strong phase-locking within stimuli but large phase variance across stimuli.
2) Do such retinal gamma band responses, both evoked and induced, directly drive some cortical gamma responses? Pilot data suggests that it can, through retinocortical coherence, our novel ERG-MEG mapping technique.
3) Several kinds of motion have now been shown to elicit massive synchrony in mammalian retina circuits. Does this also result in macroscopic high-frequency activity? If so, our experiments will finally reveal and characterize motion detection by the human retina.
4) Do efferent pathways to the retina exist in humans? We discovered that the ERG exhibits eyes-closed alpha waves strikingly similar to the classic EEG phenomenon and, leveraging our retinocortical coherence technique, that this activity is likely driven by contralateral occipital cortex. Then, can retinal responses be influenced by ongoing cortical activity?
Characterizing retinocortical interaction represents a complete paradigm shift that will be imperative for our understanding of neural synchrony in the human nervous system and enable several groundbreaking new avenues for research.
Max ERC Funding
1 499 850 €
Duration
Start date: 2016-03-01, End date: 2022-03-31
Project acronym RDRECON
Project Risky Decisions: Revealing Economic Behaviour
Researcher (PI) Steffen Andersen
Host Institution (HI) COPENHAGEN BUSINESS SCHOOL
Country Denmark
Call Details Starting Grant (StG), SH1, ERC-2014-STG
Summary Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Summary
Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be for households to change behavior? And how permanent are the changes in behavior?
The goal of the proposed research program is to understand how personal and market experiences affect financial decisions made by households, such as savings behavior, portfolio allocation, borrowing decisions, mortgage choices, and pension savings. RDRECON combines theory and evidence with an empirical research strategy that is comprised of both natural and field experiments. The theoretical component models how households make decisions. The empirical component uses both econometric and experimental methodologies to study actual household behavior across a range of economic and financial margins, as well as the influence of personal and market experiences on a household’s financial choices.
RDRECON’s strength and path-breaking innovation is its combination of administrative register data and controlled field experiments to form treatment and control groups of interest which allow empirical identification of theoretical predictions. This approach puts theory to work and overcomes the limits of identification in natural experiments. To this end, RDRECON will further our understanding of how households respond to personal and market experiences, and provide helpful insights for policy makers.
Max ERC Funding
1 461 881 €
Duration
Start date: 2015-05-01, End date: 2020-12-31
Project acronym VITAL
Project The Vitality of Disease - Quality of Life in the Making
Researcher (PI) Ayo Juhani Wahlberg
Host Institution (HI) KOBENHAVNS UNIVERSITET
Country Denmark
Call Details Starting Grant (StG), SH2, ERC-2014-STG
Summary Epidemiological reports from around the world suggest that more people than ever before are living with (especially chronic) diseases. As a consequence, sustained efforts to reduce morbidity and mortality rates have been joined by systematised efforts to improve the lives – the quality of life – of those living with disease in ways that are measurable and auditable.
VITAL will focus on the making of ‘quality of life’. While social studies of medicine have of late been marked by a ‘bio-turn’, it is apparent that within contemporary medicine, life is envisaged as much more than cellular and molecular activity; it is also a social activity and a personal experience. Not only is life sustained, it is also lived. In recent decades, morbid living – living with disease – has come to be the object of novel forms of knowledge, expertise, measurement and management while also generating new medical practices and attendant ways of relating to oneself.
VITAL suggests a shift in attention from the ways in which the social sciences have previously studied morbid living and related issues of quality of life. Rather than continue longstanding efforts to understand how people cope with disease or to refine definitions and instruments for measuring the quality of life of the sick, in VITAL we will empirically study the co-production of ‘quality of life’ within healthcare through four ethnographically-grounded studies of how ‘quality of life’ is assembled, mobilised, negotiated and practiced in concrete medical settings. The four studies will focus on how knowledge about living with disease is assembled and mobilised, on the one hand, and how morbid living is negotiated and practiced on the other.
The key outcomes of VITAL will be theoretical advancement of understandings of vitality in the 21st century beyond molecular biology and methodological innovation to facilitate empirical study of co-production processes that involve social science knowledge and practice.
Summary
Epidemiological reports from around the world suggest that more people than ever before are living with (especially chronic) diseases. As a consequence, sustained efforts to reduce morbidity and mortality rates have been joined by systematised efforts to improve the lives – the quality of life – of those living with disease in ways that are measurable and auditable.
VITAL will focus on the making of ‘quality of life’. While social studies of medicine have of late been marked by a ‘bio-turn’, it is apparent that within contemporary medicine, life is envisaged as much more than cellular and molecular activity; it is also a social activity and a personal experience. Not only is life sustained, it is also lived. In recent decades, morbid living – living with disease – has come to be the object of novel forms of knowledge, expertise, measurement and management while also generating new medical practices and attendant ways of relating to oneself.
VITAL suggests a shift in attention from the ways in which the social sciences have previously studied morbid living and related issues of quality of life. Rather than continue longstanding efforts to understand how people cope with disease or to refine definitions and instruments for measuring the quality of life of the sick, in VITAL we will empirically study the co-production of ‘quality of life’ within healthcare through four ethnographically-grounded studies of how ‘quality of life’ is assembled, mobilised, negotiated and practiced in concrete medical settings. The four studies will focus on how knowledge about living with disease is assembled and mobilised, on the one hand, and how morbid living is negotiated and practiced on the other.
The key outcomes of VITAL will be theoretical advancement of understandings of vitality in the 21st century beyond molecular biology and methodological innovation to facilitate empirical study of co-production processes that involve social science knowledge and practice.
Max ERC Funding
1 499 770 €
Duration
Start date: 2015-06-01, End date: 2021-01-31
Project acronym VOICES
Project Voices Of Individuals: Collectively Exploring Self-determination
Researcher (PI) Eilionoir Teresa Flynn
Host Institution (HI) NATIONAL UNIVERSITY OF IRELAND GALWAY
Country Ireland
Call Details Starting Grant (StG), SH2, ERC-2014-STG
Summary The right to make one’s own decisions and to have these decisions respected by law is a basic human freedom which most adults take for granted. However, for many people with disabilities (especially people with intellectual, psycho-social and other cognitive disabilities) this fundamental right has been denied – informally, in the private sphere, and formally, in the public sphere through States’ laws and policies.
Since the entry into force of the UN Convention on the Rights of Persons with Disabilities, there is an emerging consensus in human rights discourse that all people, regardless of their decision-making skills, should enjoy ‘legal capacity’ on an equal basis—that is, the right to be recognised as a person before the law and the subsequent right to have one’s decisions legally recognised. To date most of the literature on how this right should be realised has been developed by non-disabled scholars without the direct input of people with disabilities themselves.
The VOICES project will take a radical approach to develop new law reform ideas based on this concept of ‘universal legal capacity.’ Its primary objective is to develop reform proposals based on the lived experience of disability. The project will support individuals who self-identify as disabled to develop personal narratives about their experiences in exercising, or being denied, legal capacity. Through a collaborative process, legal and social science scholars will then work with people with disabilities to develop their personal narratives to frame and ground concrete proposals for law reform in previously unexplored areas – including consent to sex, contractual capacity, criminal responsibility and consent to medical treatment. In this way, the legitimacy of people with disabilities’ perspectives on the options for law reform will be validated, and this will create a powerful argument for legal change.
Summary
The right to make one’s own decisions and to have these decisions respected by law is a basic human freedom which most adults take for granted. However, for many people with disabilities (especially people with intellectual, psycho-social and other cognitive disabilities) this fundamental right has been denied – informally, in the private sphere, and formally, in the public sphere through States’ laws and policies.
Since the entry into force of the UN Convention on the Rights of Persons with Disabilities, there is an emerging consensus in human rights discourse that all people, regardless of their decision-making skills, should enjoy ‘legal capacity’ on an equal basis—that is, the right to be recognised as a person before the law and the subsequent right to have one’s decisions legally recognised. To date most of the literature on how this right should be realised has been developed by non-disabled scholars without the direct input of people with disabilities themselves.
The VOICES project will take a radical approach to develop new law reform ideas based on this concept of ‘universal legal capacity.’ Its primary objective is to develop reform proposals based on the lived experience of disability. The project will support individuals who self-identify as disabled to develop personal narratives about their experiences in exercising, or being denied, legal capacity. Through a collaborative process, legal and social science scholars will then work with people with disabilities to develop their personal narratives to frame and ground concrete proposals for law reform in previously unexplored areas – including consent to sex, contractual capacity, criminal responsibility and consent to medical treatment. In this way, the legitimacy of people with disabilities’ perspectives on the options for law reform will be validated, and this will create a powerful argument for legal change.
Max ERC Funding
891 386 €
Duration
Start date: 2015-06-01, End date: 2018-11-30
