Tamoxifen, a drug used in breast cancer treatment, may be repositioned to treat pancreatic cancer
Pancreatic cancer is the 4th leading cause of death by cancer in Europe. It has a very low survival rate with less than 1 per cent of sufferers surviving for 10 or more years. Over the last 40 years the survival rate has not significantly changed and finding an effective therapy has become a pressing challenge in cancer research. A team based at Imperial College London led by Armando Del Río Hernández, has now demonstrated that a well-known drug could be effective to fight this deadly and other forms of cancer, such as liver cancer.
Group theory, functional analysis and ergodic theory – three distinct areas of mathematics that meet within the theory of von Neumann algebras. The RIGIDITY project, funded by the ERC, aims to classify families of von Neumann algebras.
Understanding complex structures means separating irrelevant information to get to something simpler and easier to understand. When you look at something from a distance – although you don’t see all the details, you can still describe what you see. ERC grantee Balázs Szegedy has developed several mathematical tools for providing a compressed yet useful view of complex structures.
How does one infer the dynamics of a DNA minicircle in solution? How does one align the neuronal firing patterns of several neurons across individuals? These questions are intrinsically statistical, but nevertheless escape the traditional tools of statistics. The ComplexData project investigated such questions from a mathematical and an applied context.
Once limited to modelling physical problems in engineering, today Partial Differential Equations (PDEs) are used by a diverse array of fields, from natural resources to meteorology, aeronautics, oil and gas and biomedicine – to name only a few. But key mathematical issues remain unsolved, particularly when addressing their control, a must in technological transfer. The ERC-funded DYCON project aims to find answers.
Funded by the ERC, Prof. Anna Wienhard studies several new geometric forms that have been discovered over the past 20 years. These structures are closely related to the generalisation of Teichmüller space, which describes how the surface of a pretzel can be endowed with the geometry of an Escher painting.
How do you study arithmetic objects like integer points using the theory of dynamical systems? The answer is homogenous dynamics, and this connection goes both ways. The GMODGAMMADYNAMICS project, funded by an ERC grant, took a broad approach towards studying this rich interplay.
Chaotic systems are everywhere: the weather, molecules in a gas, the stock market. Small variations in initial conditions can lead to a drastically different time evolution, a phenomenon known as the butterfly effect. Systems can be classified according to how fast different, nearby initial conditions diverge in time. Supported by the ERC, Prof. Corinna Ulcigrai is investigating systems for which nearby initial conditions diverge slowly in time, to uncover mechanisms which explain their complex behaviour.
CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
