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Prof. Giulio Superti-Furga and his team work on understanding the movement of molecules across human cells. In a paper recently published on Cell Host & Microbe, they outline the significance of a single protein, SLC4A7, in phagocytosis, the body's first line of defence against infection. These results, however, go beyond the context of infectious diseases, with repercussions on our knowledge of processes like inflammation and cancer.
Scientists led by ERC grantee Emma Teeling have identified part of the molecular mechanism that gives bat species Myotis their extraordinary long and healthy lifespans. The longest-lived bats can live over 41 years of age while weighing only 7g, which is the human equivalent of some 234 years. They also maintain good health longer than many other mammals. The findings, published in the journal Science Advances, focus on the protective structures at the end of chromosomes, called telomeres. Bats may have evolved unique telomere maintenance mechanisms which allow them to repair age-related cell damage.
How do proteins trigger complex signal processing tasks, such as neurotransmission, in cells? Thanks to the development of innovative molecular simulation techniques, this ERC-funded project has brought new insights into the transmission of messages inside and between cells.
ERC grantee Prof. Maria Antonietta De Matteis studies membrane trafficking in cells and how its components interact and are regulated to guarantee a healthy cell function. Her work could revolutionise our understanding of this key biological process.
Chemical reactions are at the core of industrial processes. They are provoked to produce new molecules that will confer the desired properties to products from medicine, to cleaning agents or to fuel. With ERC funding, Prof. Jana Roithova has developed a powerful instrument for chemical analysis that could, in the long run, bring completely new ideas or design for chemical production processes.
Catalysts are essential for a lot of chemical production processes, accelerating and enhancing chemical reactions to produce plastics, medicines and fuels more efficiently. Now, thanks to EU-funded research, catalysts are being made more precise and effective with potentially significant benefits for industry and the environment, not least through the development of ultra-clean fuels.
European researchers have identified a novel approach to prevent the growth of cancer tumours and inhibit them from spreading, potentially leading to highly effective treatments with fewer side effects.
Many industries – and each of our cells – depend on emulsions. An EU-funded researcher has developed a method for studying molecules at the interface between oil nanodroplets and the water-based liquid contained in these substances. Her work advances understanding of liquid interfaces and emulsion stability, and is of great interest to industry.
While women inherit two X chromosomes, the expressions of one of them is shut down during embryonic development. Men have one X chromosome and one Y chromosome. The switching off of women’s second X chromosome is thought to compensate for the presence of only one X in males versus two in females, to balance for X-linked gene products between the sexes. X-chromosome inactivation is also one of the clearest examples of what epigenetic mechanisms do to our genetic material: the DNA of the genes on the X is still present but not actively expressed or needed. Prof. Edith Heard was awarded ERC grants to understand the intricate processes behind the phenomenon, with unexpected results that changed the way gene regulation is now looked at.
An international team of researchers, led by ERC grantee Prof Rune Linding, discovered how genetic cancer mutations attack the networks controlling human cells. This knowledge is critical for the future development of personalized precision cancer treatments.