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At the forefront of medicine, gene therapy is based on the insertion of genes into an individual's cells and tissues to treat a disease. Scientists are currently testing several approaches to this experimental technique. One of them, Prof. Seppo Ylä-Herttuala, intends to develop a novel method to treat myocardial ischemia by activating endogenous genes to propel angiogenesis. If successful, he will open a new era in gene therapy.
More than 100 million people worldwide suffer from valvular heart disease, affecting one or more of the heart’s four valves and causing breathlessness, chest pain, dizziness and fainting. If severe valvular heart disease is not properly treated, chances of surviving decrease, especially in the elderly. The only effective therapy is heart valve replacement, which may entail some risks and lead to revision surgeries. What can be done to improve safety and durability of artificial heart valves?