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CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
Prof. Gregoire Courtine believes paralysed patients will be able to walk again. This belief has represented the focus of years of work aimed at regenerating the functions of the spinal cord after injury. Thanks to his ERC funding in both 2010 and 2015, Prof. Courtine and his team have been able to develop so-called “personalised neuroprosthetics” that have led immobile rats, and more recently monkeys, to overcome their paralysis.
Ole Kamstrup, MD., MSc., is a pensioner and lives north of Copenhagen in Denmark. He has been diagnosed with Parkinson's disease ten years ago. Since 2013, Mr Kamstrup has been in contact with Professor Deniz Kirik, a neuroscientist at Lund University in Sweden. Professor Kirik, who was awarded an ERC Starting Grant in 2009, develops new therapies for Parkinson’s disease, using viral vectors to deliver therapeutic genes to the brain. An ERC Proof of Concept grant enabled him to start carrying out a market evaluation and writing a business plan for the promising therapy.
Originally published in March 2017 as part of the multimedia campaign "ERC - 10 years – 10 portraits."
Through her work with the fruit fly Drosophila santomea, Dr Virginie Orgogozo aims to answer one of the most challenging questions of modern evolutionary biology: how do observable characteristics change between species and yet remain stable in a given species?
ERC grantee Professor Deniz Kirik's spin-off company will join forces with Skåne Regional Council in southern Sweden to build a specialised hospital and a state-of-the-art gene therapy centre, the parties announced on 8 October. The new facilities are expected to be operational by 2020. They will provide researchers unique opportunities for clinical trials, while patients will gain access to the latest treatment methods for Parkinson’s disease and other illnesses.
If Darwin could have scuba dived, he would have enjoyed the East African lakes: Victoria, Malawi and Tanganyika. Here live the cichlids – a colourful fish which has evolved rapidly into thousands of species, emulating and surpassing Darwin's finches in the Galapagos. Prof. Walter Salzburger, an Austrian researcher, is using his ERC grants to study the diversity of cichlids from ecological, morphological and genetic viewpoints. He believes these unique fish provide an ideal model system to understand the "how" and the "why" in questions of evolutionary biology: questions that relate to all life on earth.
With their transparent skin and a known genome, the zebrafish larvae are emerging as a model for neuroscientists. It enables researchers to monitor large portions of the brain in an intact behaving vertebrate. Dr German Sumbre, an ERC grantee from Argentina, uses zebrafish in order to achieve a better understanding of the neural mechanisms of sensory perception, and as a means of providing new insights into neurological disorders.
The DOFOCO project aims to better understand how forests can help lessen the effects of global warming, by bringing together advanced models and data from the life and earth sciences. Such research takes an additional dimension this year, in the context of the United Nations International Year of Forests 2011.