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More than 3.5 million new people are diagnosed with heart failure every year in Europe, with a long-term prognosis of 50% mortality within four years. There is urgent need for more innovative, regenerative therapies with the potential to change the course of the condition.
The Earth is made of layers, just like a big onion, composed of different materials. However, the compounds forming these layers are not static, flowing from one stratum to another, following patterns still not entirely understood. Prof. Patrick Cordier tries to model the real conditions minerals are subjected to beneath the Earth’s crust. His aim is to understand the forces driving tectonic plates so we can better comprehend phenomena like earthquakes and volcanic eruptions.
Through her work with the fruit fly Drosophila santomea, Dr Virginie Orgogozo aims to answer one of the most challenging questions of modern evolutionary biology: how do observable characteristics change between species and yet remain stable in a given species?
Haematopoietic Stem Cells (HSCs) are blood cells located in the bone marrow. These cells are extensively used in research to develop treatments for many severe diseases, including HIV and multiple sclerosis, and their transplant is a key therapy for certain types of cancer like leukemia and multiple myeloma. However, the use of HSCs is seriously constrained by their limited availability since growing them in the lab does not produce very large quantities. There is therefore an urgent need for methods allowing scientists to multiply HSCs, without losing any of their properties.
For millions of young people around the world migration is part of their biographies. Yet we know very little about their mobility throughout their young lives because we’ve focused on just two types of moves: their first move to a new country of residence, or their parents’ migration. Prof. Mazzucato will be trying to understand the mobility patterns of youth with migrant backgrounds and how mobility affects youth's life chances. And she is the ERC's 500th grantee in the Netherlands.
Living creatures relate to their surroundings in all kinds of ways. One of these is by eating from them and excreting into them. But what is eating? Incorporating other creatures or absorbing nutrients? A need of individual bodies or a pleasure that table companions share? The ERC project EATINGBODIES has explored such questions by studying various forms of eating.
The starting point of this research project is the disproportionality between the alleged “crime” of being an undocumented migrant and the sanction of deportation. But what determines the ways in which deportation is being implemented on the ground? What are the factors that prevent or expedite implementation?
Researchers supported by the ERC have sampled magmatic gases derived from the Earth's mantle in the Eifel region in Germany. Their analysis of xenon, a rare and inert gas, sampled in bubbling mineral water could bring new insights into the origin of volatile elements, water and gases, that allowed life to develop on Earth.
A team of researchers at the Institute of Evolutionary Biology in Barcelona deciphered the genetic mechanisms responsible for the evolutionary success of animals, including humans. The findings give insight on how life evolved from its simple one-cell form to complex multi-cellular organisms. The results, published on 21/4/2016 in Cell journal, may also provide hints how the life will evolve in future.
While women inherit two X chromosomes, the expressions of one of them is shut down during embryonic development. Men have one X chromosome and one Y chromosome. The switching off of women’s second X chromosome is thought to compensate for the presence of only one X in males versus two in females, to balance for X-linked gene products between the sexes. X-chromosome inactivation is also one of the clearest examples of what epigenetic mechanisms do to our genetic material: the DNA of the genes on the X is still present but not actively expressed or needed. Prof. Edith Heard was awarded ERC grants to understand the intricate processes behind the phenomenon, with unexpected results that changed the way gene regulation is now looked at.