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Cardiovascular diseases (CVD) are a major cause of morbidity and mortality in Europe. Prevention relies on measuring traditional risk factors such as age, gender, hypertension, diabetes, hypercholesterolemia and smoking. However, many individuals, apparently at low-risk, still develop CVD. Improving predictions beyond the traditional risk factors is the challenge undertaken by Prof. Olle Melander.
The Earth is made of layers, just like a big onion, composed of different materials. However, the compounds forming these layers are not static, flowing from one stratum to another, following patterns still not entirely understood. Prof. Patrick Cordier tries to model the real conditions minerals are subjected to beneath the Earth’s crust. His aim is to understand the forces driving tectonic plates so we can better comprehend phenomena like earthquakes and volcanic eruptions.
Through her work with the fruit fly Drosophila santomea, Dr Virginie Orgogozo aims to answer one of the most challenging questions of modern evolutionary biology: how do observable characteristics change between species and yet remain stable in a given species?
Researchers supported by the ERC have sampled magmatic gases derived from the Earth's mantle in the Eifel region in Germany. Their analysis of xenon, a rare and inert gas, sampled in bubbling mineral water could bring new insights into the origin of volatile elements, water and gases, that allowed life to develop on Earth.
While women inherit two X chromosomes, the expressions of one of them is shut down during embryonic development. Men have one X chromosome and one Y chromosome. The switching off of women’s second X chromosome is thought to compensate for the presence of only one X in males versus two in females, to balance for X-linked gene products between the sexes. X-chromosome inactivation is also one of the clearest examples of what epigenetic mechanisms do to our genetic material: the DNA of the genes on the X is still present but not actively expressed or needed. Prof. Edith Heard was awarded ERC grants to understand the intricate processes behind the phenomenon, with unexpected results that changed the way gene regulation is now looked at.
During the 3rd and 2nd millennium BC, the European continent experienced important social and cultural transformations, with the introduction of metal and the emergence of new languages and identities. Recent theories suggest that these major changes were triggered by people’s migrations and cultural transmissions, challenging the perception of European prehistory as a series of unrelated local developments.
Mathematicians are similar to historians in that they are devoted to finding and interpreting patterns. Like historians, they have to deal with criticism that some theories are of little practical benefit. This is a futile debate, says mathematician Dr Francis Brown who is attending the International Congress of Mathematicians (ICM) taking place in Seoul this summer (South Korea). Through an ERC-funded project, he has developed an algorithm of immense importance to particle physics, using numbers first developed for their aesthetic appeal over 300 years ago. Sometimes the significance of mathematics – as with history – takes time to be revealed.
Artur Avila is a franco-brazilian leading mathematician and an ERC grantee since 2010. At the age of 16, he won the International Mathematical Olympic gold medal and before finishing high school, he received a scholarship for the Instituto Nacional de Matemática Pura e Aplicada (IMPA) of Rio de Janeiro. He is now senior researcher both at the National Center for Scientific Research - CNRS and IMPA. In this interview, Prof. Avila tells us about his international career and the research he conducts both in Brazil and France.
3D printers are emblematic of what the future of technology could look like. Versatile, flexible and highly adaptable, they promise to produce everything from customised furniture to transplantable organs. Yet the concept of the 3D printer, its place in our imagination, has outstripped its current technical capacity. At the Royal Institute of Technology in Sweden, Professor Frank Niklaus and his research team have set themselves a challenge: to engineer a 3D printer fitted to the modern manufacturing world, capable of producing micro- and nano-structures and, ultimately, superior micro-materials.
Who has not wanted to compose as catchy a song as Bob Dylan, Paul McCartney or Charlie Parker? French researcher Dr François Pachet has always been fascinated by the mystery of how these great musicians managed to create these amazingly iconic, and strangely addictive, melodies. Thanks to his ERC Advanced Grant, Pachet and his team are working on a software package, ‘FlowMachines’, which will help musicians or writers to explore the magic of creativity and compose music or write books in an easier way. By deciphering the intriguing relations between technology and musical creativity, he aims to offer clues to creators who wish to turn style and its various dimensions into malleable and interactive objects.