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Honey bees are an important species for ecology and economy, but their population has shrank worryingly. Prof. Philipp Engel focuses on gut microbiota, a critical factor for bee health, to understand how it evolved and diversified over time. His study addresses timely questions about evolution, ecology, microbiology and could eventually contribute to new strategies for managing bee colonies’ health.
Our soils are inhabited by millions of microorganisms; however, the majority of them lay dormant. In her ERC project, Prof. Dagmar Woebken explores the mechanisms that allow soil microorganisms to go into dormancy and thus survive unfavorable conditions. It is further the goal to reveal the environmental signals that lead to their resuscitation to perform important ecosystems functions.
CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
Prof. Giulio Superti-Furga and his team work on understanding the movement of molecules across human cells. In a paper recently published on Cell Host & Microbe, they outline the significance of a single protein, SLC4A7, in phagocytosis, the body's first line of defence against infection. These results, however, go beyond the context of infectious diseases, with repercussions on our knowledge of processes like inflammation and cancer.
Prof. Gregoire Courtine believes paralysed patients will be able to walk again. This belief has represented the focus of years of work aimed at regenerating the functions of the spinal cord after injury. Thanks to his ERC funding in both 2010 and 2015, Prof. Courtine and his team have been able to develop so-called “personalised neuroprosthetics” that have led immobile rats, and more recently monkeys, to overcome their paralysis.
For the first time ever, a team of scientists and clinicians led by the EU-funded researcher Mickael Tanter has managed to record the brain activity of a premature new-born baby during resting and during an epileptic seizure. Using a non-invasive ultrasound technology, this world premiere is a real game changer for researchers and the medical profession, offering a massive range of applications in neuroimaging and beyond. It is published today in Science Translational Medicine.
Pour la toute première fois, une équipe de scientifiques et des cliniciens dirigée par le chercheur Mickael Tanter, financé par l'UE, a réussi à enregistrer l'activité cérébrale d'un nouveau-né prématuré en phase de repos et lors d'une crise d'épilepsie. À l'aide d'une technologie d'échographie non invasive, cette première mondiale marque un véritable tournant dans le domaine de la recherche et la pratique médicale. Elle offre par ailleurs une vaste gamme d'applications en neuroimagerie et au-delà. L'étude est publiée aujourd'hui dans Science Translational Medicine.
The use and misuse of antibiotics has accelerated the emergence of drug-resistant bacterial strains, threatening our ability to treat common diseases. EU-funded research has shed new light on the mechanisms behind these microbial mutations, with implications for our understanding of diseases and resistance to treatment.
Maria Brandão de Vasconcelos, together with her colleague Filipa Matos Baptista, Henrique Veiga-Fernandes (ERC grantee), Diogo Fonseca Pereira and Sílvia Arroz Madeira, founded StemCell2MAX in 2015. The company is a biotechnology start-up, specialised in cell based therapies, including novel solutions to multiply the scarcely available blood stem cells, addressing an enormous demand for research and cancer treatment. StemCell2MAX technology is based on Prof. Veiga-Fernandes's ground-breaking discoveries in hematopoietic stem cell biology.
Originally published in March 2017 as part of the multimedia campaign "ERC - 10 years – 10 portraits."
Through her work with the fruit fly Drosophila santomea, Dr Virginie Orgogozo aims to answer one of the most challenging questions of modern evolutionary biology: how do observable characteristics change between species and yet remain stable in a given species?