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How does one infer the dynamics of a DNA minicircle in solution? How does one align the neuronal firing patterns of several neurons across individuals? These questions are intrinsically statistical, but nevertheless escape the traditional tools of statistics. The ComplexData project investigated such questions from a mathematical and an applied context.
Being able to generate human tissue in vitro in a dish is expected to revolutionise biomedical research. European researchers generated brain organoids to study the mechanisms of various neurological disorders and discover novel drugs to treat them.
CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
Originally published in May 2015
Updated in July 2018
With an aging population, Europe sees a rapid increase in the number of people affected by visual disorders requiring surgical intervention. Building on the recent advances in robotic assistance in surgery as well as in precisely targeted drug delivery therapies, Prof. Bradley Nelson has designed innovative microrobotics tools to overcome the particular difficulty of manual-performed eye surgery.
Prof. Giulio Superti-Furga and his team work on understanding the movement of molecules across human cells. In a paper recently published on Cell Host & Microbe, they outline the significance of a single protein, SLC4A7, in phagocytosis, the body's first line of defence against infection. These results, however, go beyond the context of infectious diseases, with repercussions on our knowledge of processes like inflammation and cancer.
Dr Joaquim Alves Gaspar is a man of the sea. After many years in the Portuguese Navy, he gave up plans to become an admiral in favour of pursuing a PhD in the History of Cartography. This second career led him to receive an ERC Starting Grant, the first awarded in this budding discipline. With his highly multidisciplinary team (he likes to say that, to work with him, one must be a mathematician fluent in Latin), and the experience obtained as a navigator and navigational instructor, Dr Gaspar hopes to understand how and when the first nautical charts were created. The MEDEA-CHART team is the best place in Portugal, and probably in the world, to study the history of nautical cartography, hoping that this work will provide the domain with its rightful recognition within world history.
Emulsions play a key role both in natural and industrial processes, as they allow the combination of two liquids that do not normally mix and make the blend stable. Yet, when materials solidify or freeze, the complex interactions that take place and affect the final microstructure of the solidified components, are still poorly understood. ERC grantee Sylvain Deville and his team at CNRS have showed that it is possible to use an optical imaging technique to study the freezing of emulsions while the process takes place, a novel method presented in the prestigious journal Science.
Everyone who has ever been stuck in traffic knows how frustrating and time-wasting it can be. ERC grantee Carlos Canudas de Wit is working on a global approach to improve traffic management systems using the new technologies and innovations that have not yet been fully exploited.
Severe traffic jams not only have an impact on mobility, they also raise environmental and health issues linked to fuel consumption and air and noise pollution. Prof. Ludovic Leclercq is developing new traffic control models that could tackle road congestion while integrating a green dimension.
The increase of carbon dioxide (CO2) in the atmosphere as a result of human activity is impacting the natural carbon cycle, modifying how the element travels between land and atmosphere. How will our future climate impact this exchange? How will ever-growing concentrations of greenhouse gases influence future biosphere CO2 fluxes? The answer may lie at our feet; in the soil beneath us.