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There is a common belief that concentrating poor people in the same area and isolating them from wealthier neighbourhoods actually aggravates their situation. To investigate this assumption, the DEPRIVEDHOODS project used new approaches.
CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
In urban areas, an increasing number of travellers are turning to more sustainable means of transport such as walking and cycling. The ALLEGRO project studies pedestrians and cyclists’ behaviour in traffic, a field that offers many opportunities for ground-breaking knowledge.
Severe traffic jams not only have an impact on mobility, they also raise environmental and health issues linked to fuel consumption and air and noise pollution. Prof. Ludovic Leclercq is developing new traffic control models that could tackle road congestion while integrating a green dimension.
For millions of young people around the world migration is part of their biographies. Yet we know very little about their mobility throughout their young lives because we’ve focused on just two types of moves: their first move to a new country of residence, or their parents’ migration. Prof. Mazzucato will be trying to understand the mobility patterns of youth with migrant backgrounds and how mobility affects youth's life chances. And she is the ERC's 500th grantee in the Netherlands.
While women inherit two X chromosomes, the expressions of one of them is shut down during embryonic development. Men have one X chromosome and one Y chromosome. The switching off of women’s second X chromosome is thought to compensate for the presence of only one X in males versus two in females, to balance for X-linked gene products between the sexes. X-chromosome inactivation is also one of the clearest examples of what epigenetic mechanisms do to our genetic material: the DNA of the genes on the X is still present but not actively expressed or needed. Prof. Edith Heard was awarded ERC grants to understand the intricate processes behind the phenomenon, with unexpected results that changed the way gene regulation is now looked at.
The widening gap between rich and poor is leading to segregation in more and more European cities. The rich and the poor are living at increasing distance from each other, and this can be disastrous for the social stability and competitive power of cities. These are the conclusions of joint research of Prof. Maarten van Ham, ERC grantee at Delft University of Technology, and Prof. Tiit Tammaru, Dr. Szymon Marcińczak and Prof. Sako Musterd.
An international team of researchers, led by ERC grantee Prof Rune Linding, discovered how genetic cancer mutations attack the networks controlling human cells. This knowledge is critical for the future development of personalized precision cancer treatments.