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Effective treatment for obesity remains a challenge and the only intervention proven to maintain weight loss is bariatric surgery. Intrigued by the beneficial effect that this procedure has on the composition of gut microbiota, Dr Fredrik Bäckhed explores the possibility of mimicking these changes to develop a treatment for obesity that won’t require going under the knife.
The abundant presence of a certain bacteria in our intestine, Akkermansia muciniphila, to give it its full name, is an excellent sign according to metabolism and nutrition specialist prof. Patrice Cani. With his team, they discovered the role of these bacteria in reducing cardiometabolic risk factors - like insulin resistance or hypertension – that are leading causes in the development of cardiovascular diseases and type-2 diabetes.
Teaching is certainly one of the most important professions in our society, yet its status and attractiveness have been systematically diminishing in the last decades. At the Université catholique de Louvain, Prof. Xavier Dumay is using his ERC Starting Grant to investigate the cultural and institutional transformations that have led to this "teaching profession crisis".
Severe traffic jams not only have an impact on mobility, they also raise environmental and health issues linked to fuel consumption and air and noise pollution. Prof. Ludovic Leclercq is developing new traffic control models that could tackle road congestion while integrating a green dimension.
Could migration lead to more respect for ethnic and cultural diversity not only in receiving communities but also in sending countries? By observing the effects of Polish migration to the UK and Germany, as a result of the country’s entry in the EU in 2004, Prof. Magdalena Nowicka explores possible answers to this question.
Almost 30 million children across the world are currently forcibly displaced and many of them, the unaccompanied refugee minors, are travelling without the protection and support of parents or caregivers. What do we know about the impact of their often harsh experiences on their psychological wellbeing? Dr llse Derluyn aims to gather evidence that will support the development of policies and clinical and social interventions for these unaccompanied children who face multiple traumas, also in a view to facilitate their integration in the host countries.
In 2012, 2.8 million people in the EU were diagnosed with cancer. It is the second most common cause of death in the Union – three out of 10 deaths for men, and two out of 10 deaths for women – a figure that is expected to rise due to the ageing European population. Dr Danijela Matic Vignjevic’s STARLIN project is using ERC funding to understand how normal cells become cancerous and spread.
The ability to fine-tune the functioning of blood vessels and the circulatory system is essential for combating the remodelling of the arteries that leads to heart attacks and strokes. It is also needed for the controlled repair of blood vessels after injury – which may otherwise result in a number of serious conditions. ERC grantee Professor Stefanie Dimmeler and her team at Frankfurt University are studying the role ribonucleic acid (RNA) plays in fine-tuning vascular functions – with the aim of developing new therapies for cardiovascular diseases, which are the most prevalent in Europe, due to growing obesity and longer lifespans.
The genetic heredity a person is born with isn't as impossible to change as one might think. In a study published in Cell Metabolism on 7 March 2012 Juleen Zierath, an ERC Advanced grantee 2008, and her team of researchers from the Karolinska Institutet in Sweden showed that when healthy but inactive men and women are made to exercise it actually alters chemical marks on their DNA - in a matter of minutes.
Cancer treatment and cure remains one of the main challenges of modern medicine, with more than 12 million people around the world diagnosed every year. ERC funded research, which has already shown initial positive results, proposes a new approach to define the role of stem cells in the onset and development of skin cancer. This innovative method could potentially lead to a drug that may stop the growth of skin cancer.