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At the forefront of medicine, gene therapy is based on the insertion of genes into an individual's cells and tissues to treat a disease. Scientists are currently testing several approaches to this experimental technique. One of them, Prof. Seppo Ylä-Herttuala, intends to develop a novel method to treat myocardial ischemia by activating endogenous genes to propel angiogenesis. If successful, he will open a new era in gene therapy.
More than 100 million people worldwide suffer from valvular heart disease, affecting one or more of the heart’s four valves and causing breathlessness, chest pain, dizziness and fainting. If severe valvular heart disease is not properly treated, chances of surviving decrease, especially in the elderly. The only effective therapy is heart valve replacement, which may entail some risks and lead to revision surgeries. What can be done to improve safety and durability of artificial heart valves?
Based on University of Turku's press release
For more than 3000 years, men have captured wild Asian elephants to use them for work or entertainment. In a new study published today in Nature Communications, ERC grantee Virpi Lummaa shows the harmful effects of these ongoing practices on wild-caught animals. The findings are based on detailed records from the past 100 years over a population of 5000 timber elephants from Myanmar.
CRISPR is a widely used molecular biology tool exploiting an immune process discovered in bacteria. Dr David Bikard studies CRISPR in bacterial cells, in conjunction with different DNA repair systems, to create even newer tools. He hopes to gain insight into bacterial genetics, and develop increasingly effective medical treatments.
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths. European researchers developed novel ex vivo three-dimensional organoid cultures that replicate genetic events in CRC, as tools to test novel therapeutics.
Cell transplantation is a promising new approach for organ regeneration in disease or after injury. To support the differentiation of hepatocytes from stem cells, European researchers developed ex vivo organoids which precisely mimic liver architecture.
The human brain is a remarkable organ, but how did it evolve to give us such unprecedented cognitive abilities? ERC grantee Pierre Vanderhaeghen and his team from ULB, VIB-KU Leuven turned to the genome for answers: a specific set of genes, found only in humans, could play a determinant role on the size of our brain. Published today in Cell, Vanderhaeghen's EU-funded research helps to unlock the secrets of human evolution.
'Silent killers'. This is how liver diseases are often described. But, are they really that silent? ERC grantee Mathieu Vinken, a pharmacist by training and worldwide expert in toxicology based at Vrije Universiteit Brussel (VUB), has just proven the contrary.
Prof. Giulio Superti-Furga and his team work on understanding the movement of molecules across human cells. In a paper recently published on Cell Host & Microbe, they outline the significance of a single protein, SLC4A7, in phagocytosis, the body's first line of defence against infection. These results, however, go beyond the context of infectious diseases, with repercussions on our knowledge of processes like inflammation and cancer.
Scientists led by ERC grantee Emma Teeling have identified part of the molecular mechanism that gives bat species Myotis their extraordinary long and healthy lifespans. The longest-lived bats can live over 41 years of age while weighing only 7g, which is the human equivalent of some 234 years. They also maintain good health longer than many other mammals. The findings, published in the journal Science Advances, focus on the protective structures at the end of chromosomes, called telomeres. Bats may have evolved unique telomere maintenance mechanisms which allow them to repair age-related cell damage.