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21-03-2012 | © Friedrich Miescher Institute for Biomedical Research

Investigating signaling molecules in breast cancer

Significant progress has been made in understanding breast tumour biology. However statistics indicate that the number of breast cancer patients and victims will continue to increase. Dr. Bentires-Alj, ERC Starting Grantee at the Friedrich Miescher Institute for Biomedical Research in Basel, and his team are studying the roles of the still under-explored family of protein-tyrosine phosphatases (PTPs) in both normal breast development and cancers. In a recent study, published in Nature Medicine in March 2012, Dr Bentires-Alj's team have revealed the fundamental role of the protein phosphatase SHP2 in breast cancer proliferation, invasion and metastasis.