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Two volunteers are the first above-knee amputees in the world to feel their prosthetic foot and knee in real time. Their bionic prosthesis, developed by a European team of researchers, has sensors that connect to residual nerves in the thigh. The resulting neurofeedback reduces physical and mental strain for prosthesis users as well as their phantom limb pain. They can also walk faster and with more confidence. Researchers, partly supported by ERC funds, recently reported on their achievement in Nature Medicine.
ERC grantee Juergen Brugger and his team have developed biodegradable microresonators that can be heated locally with a wireless system. Doctors could soon be using them in implants to control the release of painkillers within tissue. By Laure-Anne Pessina - Originally published on the EPFL website
How can we develop new materials that meet the extreme challenges of aerospace applications? Seizing the great potential of magnesium as a lightweight metal or making steels more resistant to failure and corrosion are two engineering challenges whose roots lie deep down at the atomic scale. Using models that bridge across scales from the atomic to the observable level, an ERC funded scientist investigates why materials behave and fail the way they do.
Honey bees are an important species for ecology and economy, but their population has shrank worryingly. Prof. Philipp Engel focuses on gut microbiota, a critical factor for bee health, to understand how it evolved and diversified over time. His study addresses timely questions about evolution, ecology, microbiology and could eventually contribute to new strategies for managing bee colonies’ health.
Prof. Gregoire Courtine believes paralysed patients will be able to walk again. This belief has represented the focus of years of work aimed at regenerating the functions of the spinal cord after injury. Thanks to his ERC funding in both 2010 and 2015, Prof. Courtine and his team have been able to develop so-called “personalised neuroprosthetics” that have led immobile rats, and more recently monkeys, to overcome their paralysis.
The use and misuse of antibiotics has accelerated the emergence of drug-resistant bacterial strains, threatening our ability to treat common diseases. EU-funded research has shed new light on the mechanisms behind these microbial mutations, with implications for our understanding of diseases and resistance to treatment.
Maria Brandão de Vasconcelos, together with her colleague Filipa Matos Baptista, Henrique Veiga-Fernandes (ERC grantee), Diogo Fonseca Pereira and Sílvia Arroz Madeira, founded StemCell2MAX in 2015. The company is a biotechnology start-up, specialised in cell based therapies, including novel solutions to multiply the scarcely available blood stem cells, addressing an enormous demand for research and cancer treatment. StemCell2MAX technology is based on Prof. Veiga-Fernandes's ground-breaking discoveries in hematopoietic stem cell biology.
Originally published in March 2017 as part of the multimedia campaign "ERC - 10 years – 10 portraits."
Haematopoietic Stem Cells (HSCs) are blood cells located in the bone marrow. These cells are extensively used in research to develop treatments for many severe diseases, including HIV and multiple sclerosis, and their transplant is a key therapy for certain types of cancer like leukemia and multiple myeloma. However, the use of HSCs is seriously constrained by their limited availability since growing them in the lab does not produce very large quantities. There is therefore an urgent need for methods allowing scientists to multiply HSCs, without losing any of their properties.
ERC grantee Marta Moita and her team use cutting-edge experimental procedures to investigate how rats and flies learn to appropriately respond to danger from other individuals. The results of her study may teach us a lot about our own brains, and shed light on diseases that impair social behaviour.
If Darwin could have scuba dived, he would have enjoyed the East African lakes: Victoria, Malawi and Tanganyika. Here live the cichlids – a colourful fish which has evolved rapidly into thousands of species, emulating and surpassing Darwin's finches in the Galapagos. Prof. Walter Salzburger, an Austrian researcher, is using his ERC grants to study the diversity of cichlids from ecological, morphological and genetic viewpoints. He believes these unique fish provide an ideal model system to understand the "how" and the "why" in questions of evolutionary biology: questions that relate to all life on earth.