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Finding ways to enlist the bacteria living in our bodies to defend against infections while better understanding their role in promoting antibiotic resistance are key to fighting this growing problem, says Dr Nassos Typas, a microbiologist at the European Molecular Biology Laboratory in Heidelberg, Germany.
Stressed plants typically stop growing. With her ERC grant, Prof. Ana Caño-Delgado has developed and is applying an innovative approach to generate drought-resistant plants that continue growing. This could play an important role in ensuring food security when water is scarce.
Maternal microbiota is crucial for the future health of a child. The transmission of microbes to offspring is a process that begins in the uterus and is influenced by the delivery method, breastfeeding and the mother’s diet. However, the mechanisms behind the protective role of maternal microbes on the baby’s health are not yet fully understood.
Until recently, lungs were believed to be sterile, but today we know that they are inhabited by microbes migrating from the mouth. Dr Randi Bertelsen has been awarded an ERC grant to investigate the role played by the oral microbiome in lung disease.
Multifunctional nanoparticles being developed by EU-funded researchers are set to revolutionise treatments for complex bone diseases, enabling novel therapies for hundreds of millions of people worldwide suffering from bone cancer, bacterial bone infections and osteoporosis.
Epithelial tissues cover all body surfaces and line most of our organs, internal cavities and passageways, including the digestive tract. Prof. Elena Martínez is engineering intestinal epithelial tissues that mimic the physiological characteristics of human intestinal tissue with the aim of advancing the in vitro modelling of diseases, the preclinical screening for drug efficacy and toxicity, and the understanding of organ development.
The use and misuse of antibiotics has accelerated the emergence of drug-resistant bacterial strains, threatening our ability to treat common diseases. EU-funded research has shed new light on the mechanisms behind these microbial mutations, with implications for our understanding of diseases and resistance to treatment.
Regulating migration has become a key priority for European countries and, according to Prof. Katja Franko, crime control practices and penal cultures have evolved across the continent as a consequence. With ERC support, she has studied these new hybrid and intertwined forms of migration and crime control policies, a phenomenon she calls ‘Crimmigration control’.
Maria Brandão de Vasconcelos, together with her colleague Filipa Matos Baptista, Henrique Veiga-Fernandes (ERC grantee), Diogo Fonseca Pereira and Sílvia Arroz Madeira, founded StemCell2MAX in 2015. The company is a biotechnology start-up, specialised in cell based therapies, including novel solutions to multiply the scarcely available blood stem cells, addressing an enormous demand for research and cancer treatment. StemCell2MAX technology is based on Prof. Veiga-Fernandes's ground-breaking discoveries in hematopoietic stem cell biology.
Originally published in March 2017 as part of the multimedia campaign "ERC - 10 years – 10 portraits."
Haematopoietic Stem Cells (HSCs) are blood cells located in the bone marrow. These cells are extensively used in research to develop treatments for many severe diseases, including HIV and multiple sclerosis, and their transplant is a key therapy for certain types of cancer like leukemia and multiple myeloma. However, the use of HSCs is seriously constrained by their limited availability since growing them in the lab does not produce very large quantities. There is therefore an urgent need for methods allowing scientists to multiply HSCs, without losing any of their properties.