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By focusing on certain actions and reactions within the brain, an EU-funded project has advanced understanding of how Alzheimer’s Disease develops. This could potentially open the door to a new era of targeted treatments.
More than 3.5 million new people are diagnosed with heart failure every year in Europe, with a long-term prognosis of 50% mortality within four years. There is urgent need for more innovative, regenerative therapies with the potential to change the course of the condition.
European researchers have designed brain-like artificial neural networks capable of numerical and spatial cognition and written language processing without any explicit training or pre-programming. Their work, based on the machine-learning approach of generative models, significantly advances the development of self-learning artificial intelligence, while also deepening understanding of human cognition.
Cardiovascular diseases (CVD) are a major cause of morbidity and mortality in Europe. Prevention relies on measuring traditional risk factors such as age, gender, hypertension, diabetes, hypercholesterolemia and smoking. However, many individuals, apparently at low-risk, still develop CVD. Improving predictions beyond the traditional risk factors is the challenge undertaken by Prof. Olle Melander.
Antibiotics are amongst the most crucial discoveries in modern medicine. However, the surge in microbial resistance to these, now common, drugs is a challenge that medical researchers work hard to tackle. Prof. Susanne Häußler from the Helmholtz Centre for Infection Research believes early diagnostic tools could shift the paradigm of how we battle this problem.
Parents may threat at the idea of their children playing in fields and sheds, but research shows that those who grew up in farms, where this is common occurrence, are less likely to suffer from allergies and asthma. Prof. Erika von Mutius leads a team of researchers, that uses this knowledge to investigate how we could treat such conditions more effectively.
Thousands of new cases of head-and-neck cancer - which includes cancer of the larynx, throat, mouth, nose and salivary glands - are diagnosed every year in Europe. Despite improvements in diagnostic and therapeutic tools, these malignant tumours still show high resistance to current treatments. Dr Daniela Thorwarth is working on tailored therapies for individual patients.
For millions of young people around the world migration is part of their biographies. Yet we know very little about their mobility throughout their young lives because we’ve focused on just two types of moves: their first move to a new country of residence, or their parents’ migration. Prof. Mazzucato will be trying to understand the mobility patterns of youth with migrant backgrounds and how mobility affects youth's life chances. And she is the ERC's 500th grantee in the Netherlands.
Different responses might be given to global challenges. For example, how should the vanishing of a glacier be tackled? Prof. Thomas Eriksen aims to understand the economic, environmental and cultural transitions the world is going through and the responses created by local communities in order to offer valuable advice to our policymakers and leaders.
In physics, scientists can predict the existence of a particle which is eventually, soon after or considerably later, observed experimentally. The Higgs boson is one of the most striking recent examples. ERC grantee Leo Kouwenhoven has recently made such a demonstration proving the existence of the “Majorana fermion”, a particle theorised in the 1930s. Detecting Majorana’s particles is not only exciting for particle physicists; thanks to their properties they could prove useful as stable “quantum bits” of information that could make quantum computers a reality.