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Effective treatment for obesity remains a challenge and the only intervention proven to maintain weight loss is bariatric surgery. Intrigued by the beneficial effect that this procedure has on the composition of gut microbiota, Dr Fredrik Bäckhed explores the possibility of mimicking these changes to develop a treatment for obesity that won’t require going under the knife.
The abundant presence of a certain bacteria in our intestine, Akkermansia muciniphila, to give it its full name, is an excellent sign according to metabolism and nutrition specialist prof. Patrice Cani. With his team, they discovered the role of these bacteria in reducing cardiometabolic risk factors - like insulin resistance or hypertension – that are leading causes in the development of cardiovascular diseases and type-2 diabetes.
According to the World Health Organisation (WHO), more than 1.9 billion adults were overweight in 2016. Of these, over 650 million were obese and therefore at a higher risk of developing cardiovascular diseases, diabetes, musculoskeletal disorders and some forms of cancers. In one of the largest studies of its kind, researchers have looked into the reasons why some people are more likely to gain weight while others manage to stay thin.
Water is a peculiar liquid. In fact, it's thanks to some of its peculiarities that our "blue" planet looks the way it does, and that life has evolved most of the characteristics we recognise today. ERC grantee Prof. Anders Nilsson has made his career out of studying water, in particular trying to understand the secret double life water leads at extremely cold temperatures.
After the birth of quantum mechanics in the early 20th century, this branch of physics evolved from being primarily the conceptual framework for the description of subatomic particle phenomena to providing inspiration for new technological applications. New hybrid architecture of quantum systems is now being developed in order to foster the implementation of cutting-edge quantum technologies.
The impact of migration on the economies of receiving countries is a fundamental question in economics. According to Prof. Christian Dustmann, current research is coming to different conclusions about the impact immigration has on wages and employment of native workers.
Acetylsalicylic acid, most commonly known as aspirin, was already part of the Egyptian pharmacopeia, used also in ancient Greece and in the Middle Ages to break fevers. Taken all over the world to kill pain and reduce inflammation, today aspirin helps to prevent heart attacks, strokes and blood clots. Its emerging role in preventing and treating cancer is on the rise too. But how does this drug act on your blood cells? ERC grantee Prof Valerie O’Donnell works on the answer.
In physics, scientists can predict the existence of a particle which is eventually, soon after or considerably later, observed experimentally. The Higgs boson is one of the most striking recent examples. ERC grantee Leo Kouwenhoven has recently made such a demonstration proving the existence of the “Majorana fermion”, a particle theorised in the 1930s. Detecting Majorana’s particles is not only exciting for particle physicists; thanks to their properties they could prove useful as stable “quantum bits” of information that could make quantum computers a reality.
Most of our actions can have an impact on the environment, be it minor, long-lasting or simply irreversible. But how can this effect be measured, avoided, predicted? What are the specificities of long-term risks and how can collective decisions be taken effectively to tackle those threats?
Prof. Michael Schneider is a leading authority in the field of cardiac molecular biology. In 2008, he obtained an ERC grant to identify the mechanisms governing self-renewal of cardiac progenitor cells, a population of stem cells located in the heart itself that might be exploited to play a key role in regenerating this vulnerable organ in heart disease. With his team at Imperial College London, he has now identified a stem cell injection that could mend broken hearts, a discovery in the field of regenerative medicine published this week in Nature Communications.