The amount of currently available biomedical data is overwhelming. Large databases exist at different scales, from genes, to proteins, to patients' histories. But what do scientists do with all this information? Serbian-born Professor Nataša Pržulj, from University College London, works with Big Data to establish patterns and gain knowledge that could revolutionise how we treat diseases.
Our immune system recognizes and fights infections in a constantly changing environment, where new pathogenic threats emerge. At the crossroad between physics and biology, Prof. Aleksandra Walczak investigates the fascinating process that allows the immune system to be always ready to adapt and evolve to face new dangers.
How do proteins trigger complex signal processing tasks, such as neurotransmission, in cells? Thanks to the development of innovative molecular simulation techniques, this ERC-funded project has brought new insights into the transmission of messages inside and between cells.
ERC grantee Prof. Maria Antonietta De Matteis studies membrane trafficking in cells and how its components interact and are regulated to guarantee a healthy cell function. Her work could revolutionise our understanding of this key biological process.
All cancers carry epigenetic alterations. But the biological function of these alterations is not well understood. In his ERC project, Prof. Christoph Bock explores their functional role by introducing these alterations into cancer and normal cells. Successful engineering of an epigenetic leukaemia could challenge the idea that all cancers are driven by genetic alterations.
Organogenesis is the process by which different cells grow, differentiate and interact with each other to create large structures, such as the heart, the brain, a limb. But what are the mechanisms behind these molecular, cellular and tissue interactions that lead to the construction of an organ? Prof. James Sharpe’s team is developing the first 3D computer model to better understand this complex process.
19-07-2017 | Clusters of most used keywords in ERC projects in the field of computational biology
Computational and systems biology are interdisciplinary sciences that have been greatly advancing in the last decades by harnessing the increased power of computation and mathematics. Their aim is to apply large-scale computational and numerical methods to the fields of molecular, cellular and structural biology, in order to answer emerging biological questions that were not possible to be tackled by traditional approaches.