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The European Innovation Council (EIC) and European Research Council (ERC) hosted a joint workshop on gene and cell therapy on 29 June 2021. Cell and gene therapy is a dynamic field of research, ranging from basic science to clinical applications as well as a promising area of medicine.
The purpose of the workshop was to explore the emerging scientific trends and potential applications of the scientific breakthroughs in an area of great importance both for our scientists and for lives of so many people around the world.
It brought together ERC grantees active in the area of the gene and cell therapy, representatives of EIC gene and therapy projects and members of the EIC Board and ERC’s Scientific Council.
Professor Jean Pierre Bourguignon, President of the ERC ad interim, said: This first joint workshop brought together the world of research and the world of innovation to talk to each other, to understand each other better, but also to inspire each other. The meeting
demonstrated again the relevance of curiosity-driven research to provide innovative solutions for industry and medicine and to address social needs. We know that the gap between frontier research and innovation is often huge, and that's why the EIC and ERC, which have different but complementary missions, join efforts to bridge this gap.
Mark Ferguson, President of the EIC Board, said: The European Innovation Council’s mission is to support transformative technologies, innovations and businesses, and we are working very closely with the ERC to ensure that our instruments are designed to provide a continuum of possibilities for excellent science to translate into impactful applications.
The analysis of ERC grants under Horizon 2020 shows the researchers’ considerable interest in cell and gene therapy. The ERC has funded more than 150 research projects in this area since 2014, worth in total over €300 million.
The researchers approach cell and gene therapy from various perspectives and methods across all life science fields and many angles rooted in physical sciences and engineering.
These ERC projects, even though driven by the interest of principal investigators, are highly relevant to EU priories in health, biotechnology, nanotechnology and advanced materials.
Under Horizon Europe, the EIC has just published a call on emerging technologies in cell and gene therapy. The aim of this EIC Pathfinder Challenge is to fund proposals focused on novel concept-based technologies that can contribute to the development of more effective cell and gene therapy (CGT) treatments, and on technological solutions beyond the state-of-the-art, that have the potential to overcome critical challenges currently being faced by the cell and gene therapy research community and innovation-based industry.
The EIC and ERC will continue their collaboration.
Presentations and videos
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Welcome and Introduction by Prof. Bourguignon and Prof. Ferguson (video)
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Plenary presentation by Dr Arzimanoglou (video)
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Roundtable discussion (video)
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From cell to cell: extracellular vesicles as delivery platform, Antonella Bongiovanni (pdf)
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Organoids to model, diagnose and treat human diseases, Hans Clevers (pdf)
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Cell therapy for DMD - Giulio Cossu, MD (pdf)
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Epithelial Stem Cells in Cell and Gene Therapy, Michele De Luca (pdf)
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Immune Niches for Cancer ImmunoTherapy Enhancement, Halas O. (pdf)
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Non-viral, Sleeping Beauty Transposonbased Gene Therapy, Zsuzsanna Izsvák (pdf)
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Coiled-coil mediated tethering of CRISPR/Cas and exonucleases for enhanced genome editing, Roman Jerala (pdf)
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Regeneration in multicellular systems. Prof. Prisca Liberali (pdf)
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Engineering next-generation organoid models, Matthias P. Lutolf (pdf)
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Organs-on-chip models of inherited small vessel diseases in drug discovery, Christine Mummery (pdf)
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Genetic Engineering of Hematopoiesis to Treat Inherited Diseases and Cancer, Luigi Naldini (pdf)
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NEWmRNA–A Synthetic Biology of mRNA for Enabling New Roads in Therapy, Sven Panke (pdf)
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Extracellular vesiclesvesicles for therapeutic therapeutic RNA delivery RNA deliveryRNA delivery RNA, Pieter Vader (pdf)
- Site-directed RNA base editing – A marketable innovation, Stafforst, T (ppt)